Reaction profile

The FDA adverse-event record for unable to rise

1,420 FDA adverse-event reports reference unable to rise (VeDDRA 2045). See the species, breeds, and drugs most associated with it below.

1,420
reports citing this reaction
37.6%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
1,420
Total Reports
534
Deaths
37.6%
Death Rate

Species Most Affected

Dog 1,209
Cat 116
Cattle 52
Horse 23
Pig 11
Goat 3
Turkey 3
Sheep 2
Chicken 1

Breeds Most Affected

Retriever - Labrador 192
Crossbred Canine/dog 93
Retriever - Golden 78
Domestic Shorthair 71
Shepherd Dog - German 67
Boxer (German Boxer) 42
Chihuahua 35
Dog (unknown) 32
Terrier - Yorkshire 27
Shepherd Dog - Australian 25

Associated Drugs

Bedinvetmab 224
Carprofen 160
Milbemycin Oxime + Spinosad 148
Gabapentin 114
Afoxolaner 77
Spinosad 72
Maropitant Citrate 62
Moxidectin 61
Fluralaner Chew Tablets 59
Trilostane 55
Oclacitinib Maleate 50
Grapiprant 45
Tramadol 43
Prednisone 43
Sarolaner 43
Ivermectin + Pyrantel As Pamoate Salt 41
Milbemycin Oxime + Praziquantel 38
Polysulfated Glycosaminoglycan 36
Cefovecin 34
Pyrantel Pamoate;Sarolaner 32

Unable to rise Reaction Insights

1,420 reports name Unable to rise; 534 recorded a death outcome (37.6% of reported events, not a population-level mortality rate). VeDDRA code: 2045.

By species: Dog (1,209 reports), Cat (116 reports), Cattle (52 reports). By breed: Retriever - Labrador (192), Crossbred Canine/dog (93), Retriever - Golden (78).

Most co-reported drugs: Bedinvetmab (224 reports), Carprofen (160 reports), Milbemycin Oxime + Spinosad (148 reports), Gabapentin (114 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.