Reaction profile

The FDA adverse-event record for staggering

1,384 FDA adverse-event reports reference staggering (VeDDRA 655). See the species, breeds, and drugs most associated with it below.

1,384
reports citing this reaction
16.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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1,384
Total Reports
233
Deaths
16.8%
Death Rate

Species Most Affected

Dog 1,099
Cat 179
Cattle 69
Horse 26
Sheep 4
Goat 3
Human 2
Other Birds 1
Donkey 1

Breeds Most Affected

Retriever - Labrador 125
Domestic Shorthair 109
Crossbred Canine/dog 97
Chihuahua 52
Shepherd Dog - German 48
Terrier - Yorkshire 48
Retriever - Golden 42
Shih Tzu 39
Dog (unknown) 32
Boxer (German Boxer) 28

Associated Drugs

Milbemycin Oxime + Spinosad 161
Ivermectin + Pyrantel As Pamoate Salt 117
Spinosad 110
Afoxolaner 94
Carprofen 90
Bedinvetmab 50
Fluralaner Chew Tablets 47
Ivermectin 45
Moxidectin 41
Cefovecin 31
Maropitant Citrate 29
Sarolaner 28
Selamectin 27
Milbemycin Oxime + Praziquantel 25
Ivermectin, Pyrantel 23
Gabapentin 23
Pyrantel Pamoate;Sarolaner 21
Insulin Injectable Vial 20
Fluralaner 13.64% 12-Week Chew 18
Trilostane 17

Staggering Reaction Insights

1,384 reports name Staggering; 233 recorded a death outcome (16.8% of reported events, not a population-level mortality rate). VeDDRA code: 655.

By species: Dog (1,099 reports), Cat (179 reports), Cattle (69 reports). By breed: Retriever - Labrador (125), Domestic Shorthair (109), Crossbred Canine/dog (97).

Most co-reported drugs: Milbemycin Oxime + Spinosad (161 reports), Ivermectin + Pyrantel As Pamoate Salt (117 reports), Spinosad (110 reports), Afoxolaner (94 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.