Reaction profile

The FDA adverse-event record for skin swelling

282 FDA adverse-event reports reference skin swelling (VeDDRA 969). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#901 of 2,481
by report volume (all reactions)
282
reports citing this reaction
7.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Skin swelling has 282 reports now versus 279 in that prior snapshot: 3 more (1.1%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Skin swelling changes

FDA AER · VeDDRA plate

Code 969 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 282 reports
  • DEATH-PAR 7.4%
  • MID-PACK #901/2481
  • PHOTO-FINISH Bloated stomach
  • SPECIES-DOG Dog · 195
  • DRUG-LEAD Moxidectin · 27
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Bloated stomach (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Skin swelling

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Cardiomyopathy · near283Bloated stomach · near282Gastrointestinal fore… · near282Pericardial effusion · near282Skin swelling · this reaction282Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Skin swelling

Skin swelling: low death-coded share in the FDA AER plate

Signature read: Skin swelling's 7.4% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 21 of 282 reports (7.4% of named reports). Nearest volume peer: Bloated stomach (±0 reports). Lead species Dog (195). Lead co-reported drug Moxidectin (27).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Moxidectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 195
Cat 38
Human 23
Horse 11
Cattle 10
Rabbit 3
Pig 2

Breeds Most Affected

Unknown 25
Retriever - Labrador 22
Domestic Shorthair 20
Crossbred Canine/dog 18
Chihuahua 10
Pit Bull 10
Terrier - Bull - American Pit 9
Dachshund (unspecified) 7
Shepherd Dog - German 7
Retriever - Golden 7

Associated Drugs

Moxidectin 27
Afoxolaner 19
Milbemycin Oxime + Spinosad 18
Carprofen 16
Imidacloprid + Moxidectin 13
Cefovecin 13
Oclacitinib Maleate 13
Fluralaner Chew Tablets 12
Spinosad 11
Gabapentin 11
Meloxicam 10
Melarsomine Dihydrochloride Injection 9
Maropitant Citrate 8
Ivermectin + Pyrantel As Pamoate Salt 7
Prednisone 7
Anti-Il31 Mab Mcs Lot #1283563 7
Tigilanol Tiglate 7
Bedinvetmab 7
Cephalexin 6
Enrofloxacin 6

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Skin swelling, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (282 here).

Similar death-coded share

Nearest other reactions by death-coded share (7.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Skin swelling (#901 of 2,481 by report volume); death-coded 7.4%. PlainBreed reaction plate · death-coded share stamp 7.4% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →