Reaction profile

The FDA adverse-event record for pr-ear(s), lesion(s)

389 FDA adverse-event reports reference pr-ear(s), lesion(s) (VeDDRA 99610). See the species, breeds, and drugs most associated with it below.

389
reports citing this reaction
4.4%
death-coded share
Dog
most-affected species
Clotrimazole + Gentamicin + Mometasone
most-associated drug
Verify with FDA CVM →
389
Total Reports
17
Deaths
4.4%
Death Rate

Species Most Affected

Dog 373
Cat 13
Cattle 3

Breeds Most Affected

Retriever - Labrador 47
Terrier - Yorkshire 23
Chihuahua 18
Unknown 17
Boxer (German Boxer) 17
Retriever - Golden 15
Pit Bull 15
Shepherd Dog - German 14
Shih Tzu 12
Pug 10

Associated Drugs

Clotrimazole + Gentamicin + Mometasone 275
Betamethasone Valerate, Usp + Clotrimazole, Usp + Gentamicin Sulfate, Usp 47
Neomycin Sulfate, Usp + Nystatin, Usp + Thiostrepton, [Usp] + Triamcinolone Acetonide, Usp 41
Oclacitinib Maleate 12
Cefovecin 6
Cefovecin Sodium 2
Methylprednisolone Acetate 2
Tildipirosin 2
Ivermectin 1
Imidacloprid + Moxidectin 1
Nitenpyram 1
Florfenicol, Flunixin 1
Vaccine 1
Dexamethasone 1
Insulin 1
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1
Famotidine 1
Mirtazapine 1
Hetastarch 1
Enrofloxacin 1

PR-EAR(S), LESION(S) Reaction Insights

389 reports name PR-EAR(S), LESION(S); 17 recorded a death outcome (4.4% of reported events, not a population-level mortality rate). VeDDRA code: 99610.

By species: Dog (373 reports), Cat (13 reports), Cattle (3 reports). By breed: Retriever - Labrador (47), Terrier - Yorkshire (23), Chihuahua (18).

Most co-reported drugs: Clotrimazole + Gentamicin + Mometasone (275 reports), Betamethasone Valerate, Usp + Clotrimazole, Usp + Gentamicin Sulfate, Usp (47 reports), Neomycin Sulfate, Usp + Nystatin, Usp + Thiostrepton, [Usp] + Triamcinolone Acetonide, Usp (41 reports), Oclacitinib Maleate (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.