Reaction profile

The FDA adverse-event record for not sleeping

1,136 FDA adverse-event reports reference not sleeping (VeDDRA 140). See the species, breeds, and drugs most associated with it below.

1,136
reports citing this reaction
6.8%
death-coded share
Dog
most-affected species
Buprenorphine
most-associated drug
Verify with FDA CVM →
1,136
Total Reports
77
Deaths
6.8%
Death Rate

Species Most Affected

Dog 726
Cat 408
Horse 1
Unknown 1

Breeds Most Affected

Domestic Shorthair 217
Cat (unknown) 70
Retriever - Labrador 58
Crossbred Canine/dog 53
Shih Tzu 36
Maltese 32
Terrier - Yorkshire 30
Retriever - Golden 30
Chihuahua 29
Dog (unknown) 27

Associated Drugs

Buprenorphine 361
Milbemycin Oxime + Spinosad 100
Isoflurane 78
Maropitant Citrate 71
Robenacoxib 70
Gabapentin 57
Afoxolaner 56
Dexmedetomidine 55
Propofol 48
Ketamine 46
Carprofen 45
Cefovecin Sodium 45
Trilostane 44
Butorphanol 44
Ivermectin + Pyrantel As Pamoate Salt 41
Pyrantel Pamoate;Sarolaner 41
Midazolam 39
Spinosad 37
Fipronil 9.8%/S-Methoprene 8.8%/Cyphenothrin 5.2% Squeeze-On 37
Bedinvetmab 37

Not sleeping Reaction Insights

1,136 reports name Not sleeping; 77 recorded a death outcome (6.8% of reported events, not a population-level mortality rate). VeDDRA code: 140.

By species: Dog (726 reports), Cat (408 reports), Horse (1 reports). By breed: Domestic Shorthair (217), Cat (unknown) (70), Retriever - Labrador (58).

Most co-reported drugs: Buprenorphine (361 reports), Milbemycin Oxime + Spinosad (100 reports), Isoflurane (78 reports), Maropitant Citrate (71 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.