Reaction profile

The FDA adverse-event record for low tear flow

148 FDA adverse-event reports reference low tear flow (VeDDRA 1102). See the species, breeds, and drugs most associated with it below.

148
reports citing this reaction
1.4%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
148
Total Reports
2
Deaths
1.4%
Death Rate

Species Most Affected

Dog 144
Cat 4

Breeds Most Affected

Chihuahua 15
Shih Tzu 12
Maltese 11
Crossbred Canine/dog 11
Terrier (unspecified) 7
Spaniel - King Charles Cavalier 4
Retriever - Labrador 4
Bulldog 4
Pinscher - Miniature 4
Terrier - Yorkshire 4

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 50
Oclacitinib Maleate 22
Maropitant Citrate 17
Prednisone 13
Carprofen 12
Ofloxacin 12
Florfenicol, Terbinafine, Betamethasone Acetate 12
Pilocarpine 10
Enrofloxacin 9
Tobramycin 9
Betamethasone + Florfenicol + Terbinafine 8
Ear Cleaner (Unknown) 7
Meloxicam 7
Bordetella Vaccine 7
Artificial Tears 6
Cefovecin Sodium 6
Cefpodoxime 6
Oclacitinib 6
Pyrantel Pamoate;Sarolaner 6
Milbemycin Oxime + Spinosad 5

Low tear flow Reaction Insights

148 reports name Low tear flow; 2 recorded a death outcome (1.4% of reported events, not a population-level mortality rate). VeDDRA code: 1102.

By species: Dog (144 reports), Cat (4 reports). By breed: Chihuahua (15), Shih Tzu (12), Maltese (11).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (50 reports), Oclacitinib Maleate (22 reports), Maropitant Citrate (17 reports), Prednisone (13 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.