Reaction profile

The FDA adverse-event record for application site dry skin

143 FDA adverse-event reports reference application site dry skin (VeDDRA 2514). See the species, breeds, and drugs most associated with it below.

143
reports citing this reaction
1.4%
death-coded share
Cat
most-affected species
Fluralaner Spot-On Solution
most-associated drug
Verify with FDA CVM →
143
Total Reports
2
Deaths
1.4%
Death Rate

Species Most Affected

Cat 93
Dog 36
Human 10
Cattle 2
Horse 2

Breeds Most Affected

Domestic Shorthair 70
Unknown 10
Domestic Longhair 6
Domestic Mediumhair 5
Terrier - Yorkshire 4
Cat (unknown) 3
Cattle (other) 2
Crossbred Feline/cat 2
Shepherd Dog - Australian 2
Siamese 2

Associated Drugs

Fluralaner Spot-On Solution 29
Mirtazapine 18
Imidacloprid + Moxidectin 17
Selamectin;Sarolaner 17
Selamectin 15
Fluralaner/Moxidectin Spot-On 15
Flumethrin-Imidacloprid 8
Emodepside + Praziquantel 5
Buprenorphine 5
Chlorhexidine Gluconate + Climbazole + Phytosphingosine Salicyloyl 4
Rabies Vaccine 3
Gabapentin 3
Antibiotic 2
Methylprednisolone Acetate 2
Maropitant Citrate 2
Fluralaner Chew Tablets 2
Cefpodoxime 2
Prednisone 2
Dexmedetomidine 2
Propofol 2

Application site dry skin Reaction Insights

143 reports name Application site dry skin; 2 recorded a death outcome (1.4% of reported events, not a population-level mortality rate). VeDDRA code: 2514.

By species: Cat (93 reports), Dog (36 reports), Human (10 reports). By breed: Domestic Shorthair (70), Unknown (10), Domestic Longhair (6).

Most co-reported drugs: Fluralaner Spot-On Solution (29 reports), Mirtazapine (18 reports), Imidacloprid + Moxidectin (17 reports), Selamectin;Sarolaner (17 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.