Reaction profile

The FDA adverse-event record for injection site itching

96 FDA adverse-event reports reference injection site itching (VeDDRA 95). See the species, breeds, and drugs most associated with it below.

96
reports citing this reaction
2.1%
death-coded share
Dog
most-affected species
Frunevetmab
most-associated drug
Verify with FDA CVM →
96
Total Reports
2
Deaths
2.1%
Death Rate

Species Most Affected

Dog 59
Cat 25
Human 6
Horse 4
Goat 2

Breeds Most Affected

Domestic Shorthair 18
Unknown 6
Shepherd Dog - German 5
Crossbred Canine/dog 3
Shih Tzu 3
Chihuahua 3
Terrier - Yorkshire 3
Beagle 3
Dachshund (unspecified) 2
Terrier - Irish Soft-coated Wheaten 2

Associated Drugs

Frunevetmab 14
Moxidectin 12
Maropitant Citrate 10
Bedinvetmab 10
Cefovecin 8
Prednisone 6
Polysulfated Glycosaminoglycan 5
Tigilanol Tiglate 5
Rabies Vaccine, Killed Virus 4
Desoxycorticosterone Pivalate 4
Milbemycin Oxime + Praziquantel 4
Gabapentin 4
Ceftiofur Crystalline Free Acid 3
Melarsomine Dihydrochloride 3
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 3
Fluoxetine 3
Melarsomine Dihydrochloride Injection 2
Recombinant Human Insulin 2
Methylprednisolone Acetate 2
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 2

Injection site itching Reaction Insights

96 reports name Injection site itching; 2 recorded a death outcome (2.1% of reported events, not a population-level mortality rate). VeDDRA code: 95.

By species: Dog (59 reports), Cat (25 reports), Human (6 reports). By breed: Domestic Shorthair (18), Unknown (6), Shepherd Dog - German (5).

Most co-reported drugs: Frunevetmab (14 reports), Moxidectin (12 reports), Maropitant Citrate (10 reports), Bedinvetmab (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.