Reaction profile

The FDA adverse-event record for increased yawning

73 FDA adverse-event reports reference increased yawning (VeDDRA 2501). See the species, breeds, and drugs most associated with it below.

73
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
73
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Dog 56
Horse 11
Cat 5
Human 1

Breeds Most Affected

Chihuahua 7
Dog (unknown) 4
Maltese 4
Quarter Horse 4
Domestic Shorthair 4
Terrier - Yorkshire 3
Poodle - Miniature 3
Terrier (unspecified) 3
Unknown 2
Warmblood (unspecified) 2

Associated Drugs

Milbemycin Oxime + Spinosad 26
Afoxolaner 8
Ivermectin + Pyrantel As Pamoate Salt 4
Imidacloprid + Moxidectin 4
Spinosad 3
Fluralaner Chew Tablets 3
Oclacitinib Maleate 3
Ivermectin + Praziquantel 3
Firocoxib 2
Sarolaner 2
Ceftiofur Crystalline Free Acid 2
Selamectin 2
Milbemycin Oxime + Praziquantel 2
Nitenpyram 2
Fipronil 1
Famotidine 1
Hydroxyzine 1
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 1
Tulathromycin 1
Tiludronate Disodium 1

Increased yawning Reaction Insights

73 reports name Increased yawning; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 2501.

By species: Dog (56 reports), Horse (11 reports), Cat (5 reports). By breed: Chihuahua (7), Dog (unknown) (4), Maltese (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (26 reports), Afoxolaner (8 reports), Ivermectin + Pyrantel As Pamoate Salt (4 reports), Imidacloprid + Moxidectin (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.