Reaction profile

The FDA adverse-event record for increased yawning

80 FDA adverse-event reports reference increased yawning (VeDDRA 2501). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1503 of 2,481
by report volume (all reactions)
80
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Increased yawning has 80 reports now versus 74 in that prior snapshot: 6 more (8.1%).

Report change
+6
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Increased yawning changes

FDA AER · VeDDRA plate

Code 2501 VOL-LOW

VOL-LOW · DEATH-RARE · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 80 reports
  • DEATH-RARE 0.0%
  • MID-PACK #1503/2481
  • PHOTO-FINISH Cardiac neoplasm
  • SPECIES-DOG Dog · 58
  • DRUG-LEAD Milbemycin Oxime… · 26
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Cardiac neoplasm (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Increased yawning

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Cardiac neoplasm · near80Dilated renal pelvis · near80Erythema multiforme · near80Hernia NOS · near80Increased yawning · this rea…80Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Increased yawning

Increased yawning: low death-coded share in the FDA AER plate

Signature read: Increased yawning's 0.0% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 0 of 80 reports (0.0% of named reports). Nearest volume peer: Cardiac neoplasm (±0 reports). Lead species Dog (58). Lead co-reported drug Milbemycin Oxime + Spinosad (26).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 58
Horse 16
Cat 5
Human 1

Breeds Most Affected

Chihuahua 7
Maltese 6
Quarter Horse 6
Horse (unknown) 4
Dog (unknown) 4
Domestic Shorthair 4
Terrier - Yorkshire 3
Poodle - Miniature 3
Terrier (unspecified) 3
Warmblood (unspecified) 2

Associated Drugs

Milbemycin Oxime + Spinosad 26
Afoxolaner 8
Ceftiofur Crystalline Free Acid 5
Ivermectin + Pyrantel As Pamoate Salt 4
Imidacloprid + Moxidectin 4
Spinosad 3
Fluralaner Chew Tablets 3
Oclacitinib Maleate 3
Ivermectin + Praziquantel 3
Gentamicin 3
Firocoxib 2
Sarolaner 2
Selamectin 2
Nitenpyram 2
Milbemycin Oxime + Praziquantel 2
Pergolide Mesylate 2
Pergolide 2
Flunixin Meglumine 2
Flunixin Meglumine Injectable 2
Clodronate Disodium 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Increased yawning, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (80 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Increased yawning (#1503 of 2,481 by report volume); death-coded 0.0%. PlainBreed reaction plate · death-coded share stamp 0.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →