Reaction profile

The FDA adverse-event record for application site hot spot

101 FDA adverse-event reports reference application site hot spot (VeDDRA 2407). See the species, breeds, and drugs most associated with it below.

101
reports citing this reaction
0.0%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
101
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Cat 75
Dog 26

Breeds Most Affected

Domestic Shorthair 42
Domestic Longhair 11
Domestic Mediumhair 9
Maine Coon 5
Bulldog 3
Retriever - Golden 3
Siamese 3
Bichon Frise 2
Cat (other) 2
Ragdoll 2

Associated Drugs

Selamectin 26
Fluralaner Spot-On Solution 24
Selamectin;Sarolaner 19
Imidacloprid + Moxidectin 12
Fluralaner/Moxidectin Spot-On 6
Flumethrin-Imidacloprid 3
Rabies Vaccine 3
Ivermectin + Pyrantel As Pamoate Salt 3
Enrofloxacin 3
Emodepside + Praziquantel 3
Imidacloprid, Flumethrin 3
Indoxacarb Topic Oily Solution 2
Febantel + Praziquantel + Pyrantel Pamoate 2
Fipronil 9.8% / S-Methoprene 8.8% / Pyriproxyfen 0.25% Topical Solution 2
Imidacloprid + Permethrin + Pyriproxyfen 2
Rhinotracheitis, Calici Virus, Panleukopenia 2
Fluralaner 13.64% 12-Week Chew 2
Eprinomectin + Esafoxolaner + Praziquantel 2
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 1
Fipronil 9.8%/S-Methoprene 8.8%/Cyphenothrin 5.2% Squeeze-On 1

Application site hot spot Reaction Insights

101 reports name Application site hot spot; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 2407.

By species: Cat (75 reports), Dog (26 reports). By breed: Domestic Shorthair (42), Domestic Longhair (11), Domestic Mediumhair (9).

Most co-reported drugs: Selamectin (26 reports), Fluralaner Spot-On Solution (24 reports), Selamectin;Sarolaner (19 reports), Imidacloprid + Moxidectin (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.