Reaction profile

The FDA adverse-event record for enlarged lymph nodes (generalised)

329 FDA adverse-event reports reference enlarged lymph nodes (generalised) (VeDDRA 2426). See the species, breeds, and drugs most associated with it below.

329
reports citing this reaction
26.7%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
329
Total Reports
88
Deaths
26.7%
Death Rate

Species Most Affected

Dog 301
Cat 26
Cattle 1
Ferret 1

Breeds Most Affected

Retriever - Labrador 42
Crossbred Canine/dog 20
Domestic Shorthair 18
Dog (unknown) 15
Retriever - Golden 13
Shepherd Dog - German 12
Boxer (German Boxer) 12
Chihuahua 10
Terrier - Yorkshire 8
Schnauzer - Miniature 6

Associated Drugs

Oclacitinib Maleate 84
Bedinvetmab 35
Prednisone 30
Carprofen 25
Maropitant Citrate 25
Fluralaner Chew Tablets 22
Gabapentin 19
Trilostane 17
Anti-Il31 Mab Mcs Lot #1283563 17
Afoxolaner 15
Grapiprant 13
Metronidazole 13
Enrofloxacin 11
Cyclosporine 11
Lotilaner 10
Doxycycline 9
Famotidine 8
Moxidectin 8
Milbemycin Oxime + Praziquantel 8
Verdinexor 8

Enlarged lymph nodes (generalised) Reaction Insights

329 reports name Enlarged lymph nodes (generalised); 88 recorded a death outcome (26.7% of reported events, not a population-level mortality rate). VeDDRA code: 2426.

By species: Dog (301 reports), Cat (26 reports), Cattle (1 reports). By breed: Retriever - Labrador (42), Crossbred Canine/dog (20), Domestic Shorthair (18).

Most co-reported drugs: Oclacitinib Maleate (84 reports), Bedinvetmab (35 reports), Prednisone (30 reports), Carprofen (25 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.