Elevated alanine aminotransferase (ALT)
VeDDRA Code: 2050
15,315 adverse event reports referencing this reaction
15,315
Total Reports
2,558
Deaths
1670.0%
Death Rate
Species Most Affected
Dog 13,754
Cat 1,534
Human 9
Horse 7
Ferret 3
Cattle 3
Rabbit 1
Other Canids 1
Other 1
Other Rodents 1
Breeds Most Affected
Retriever - Labrador 2,462
Crossbred Canine/dog 1,061
Domestic Shorthair 912
Chihuahua 612
Retriever - Golden 457
Shih Tzu 426
Shepherd Dog - German 349
Terrier - Yorkshire 343
Maltese 332
Beagle 304
Associated Drugs
Carprofen 3,152
Trilostane 1,902
Milbemycin Oxime + Spinosad 1,215
Maropitant Citrate 1,102
Oclacitinib Maleate 1,076
Moxidectin 713
Afoxolaner 630
Gabapentin 591
Bedinvetmab 531
Grapiprant 499
Prednisone 493
Fluralaner Chew Tablets 452
Spinosad 439
Ivermectin + Pyrantel As Pamoate Salt 417
Meloxicam 378
Melarsomine Dihydrochloride 349
Famotidine 341
Tramadol 335
Metronidazole 333
Deracoxib 321
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.