Reaction profile

The FDA adverse-event record for apprehension

473 FDA reports name apprehension, a high-volume reaction in the CVM extract (VeDDRA 1055). Plate stamps and neighbourhood peers follow.

#661 of 2,481
by report volume (all reactions)
473
reports citing this reaction
4.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Apprehension has 473 reports now versus 473 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Apprehension changes

FDA AER · VeDDRA plate

Code 1055 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 473 reports
  • DEATH-LOW 4.7%
  • MID-PACK #661/2481
  • PHOTO-FINISH Paralysis
  • SPECIES-DOG Dog · 383
  • DRUG-LEAD Spinosad · 52
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Paralysis (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Apprehension

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abscess NOS · near474Apprehension · this reaction473Paralysis · near473Heart failure · near472Welt · near472Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Apprehension

Apprehension: low death-coded share in the FDA AER plate

Signature read: Apprehension's 4.7% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is upper-third scale: 473 named reports in the openFDA extract. Death-coded share is lower-third: 22 of 473 reports (4.7% of named reports). Nearest volume peer: Paralysis (±0 reports). Lead species Dog (383). Lead co-reported drug Spinosad (52).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 383
Cat 83
Horse 5
Cattle 1
Sheep 1

Breeds Most Affected

Crossbred Canine/dog 68
Domestic (unspecified) 43
Retriever - Labrador 33
Domestic Shorthair 24
Chihuahua 16
Terrier - Yorkshire 13
Retriever - Golden 13
Shih Tzu 12
Dog (unknown) 12
Shepherd Dog - German 11

Associated Drugs

Spinosad 52
Nitenpyram 29
Cyclosporine A 24
Cyclosporine 22
Fluoxetine 20
Carprofen 20
Selamectin 19
Deracoxib 18
Imidacloprid, Moxidectin 15
Milbemycin Oxime + Spinosad 15
Ivermectin, Pyrantel 14
Milbemycin, Lufenuron 12
Melarsomine Dihydrochloride 10
Milbemycin 9
Spinosad, Milbemycin 9
Fenbendazole 8
Estriol 8
Afoxolaner 8
Pimobendan 7
Imidacloprid + Moxidectin 7

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Apprehension, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (473 here).

Similar death-coded share

Nearest other reactions by death-coded share (4.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Apprehension (#661 of 2,481 by report volume); death-coded 4.7%. PlainBreed reaction plate · death-coded share stamp 4.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →