Drug profile

The FDA adverse-event record for Ivermectin And Pyrantel

64 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ivermectin And Pyrantel. Species, reactions, and outcomes follow.

#977 of 2,679
by report volume (all drugs)
64
adverse-event reports
4.7%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Ivermectin And Pyrantel ranks #976 of 2679 by total reports (64) and #802 of 1130 by death-coded share (4.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#976
This drug, reports of 2679
#802
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Ivermectin And Pyrantel has 64 reports now versus 56 in that prior snapshot: 8 more (14.3%).

Report change
+8
Death-coded reports
+0
Death-coded share
−0.7 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Ivermectin And Pyrantel changes

Signature read: Ivermectin And Pyrantel's 4.7% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
64
Total Reports
3
Deaths Reported
4.7%
Death-coded share of reports

Active Ingredients

Ivermectin And Pyrantel

Administration Routes

OralUnknown

Species Affected

Dog 64

Most Affected Breeds

Retriever - Labrador 11
Crossbred Canine/dog 5
Retriever - Golden 5
Chihuahua 4
Terrier (unspecified) 3
Pointing Dog - Hungarian Short-haired (Vizsla) 3
Shepherd Dog - German 3
Terrier - Bull - American Pit 3
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2
Collie - Border 2

Most Reported Reactions

Lack of efficacy (endoparasite) - heartworm 12
INEFFECTIVE, HEARTWORM LARVAE 10
Vomiting 9
Elevated alanine aminotransferase (ALT) 7
Lack of efficacy - NOS 5
Seizure NOS 5
Unsteady gait 5
Weight loss 4
Not eating 4
Decreased appetite 4
Lethargy (see also Central nervous system depression in Neurological) 4
Elevated serum alkaline phosphatase (ALP) 4

Outcome Breakdown

Ongoing
31 (48.4%)
Outcome Unknown
18 (28.1%)
Recovered/Normal
11 (17.2%)
Died
2 (3.1%)
Recovered with Sequela
1 (1.6%)
Euthanized
1 (1.6%)

Ivermectin And Pyrantel: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Ivermectin And Pyrantel, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (64 here).

Similar death-coded share

Nearest other drugs by death-coded share (4.7% here), distinct from the volume row.

What to do with this drug

  • Compare Ivermectin And Pyrantel's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Ivermectin And Pyrantel (#977 of 2,679 by report volume); death-coded 4.7%. PlainBreed drug row · death-coded share stamp 4.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →