Drug profile

The FDA adverse-event record for Polyethylene Glycol

80 FDA reports name Polyethylene Glycol, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#874 of 2,679
by report volume (all drugs)
80
adverse-event reports
20.0%
death-coded share
Cat
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Polyethylene Glycol ranks #871 of 2679 by total reports (80) and #242 of 1130 by death-coded share (20.0%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#871
This drug, reports of 2679
#242
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Polyethylene Glycol has 80 reports now versus 75 in that prior snapshot: 5 more (6.7%).

Report change
+5
Death-coded reports
+2
Death-coded share
+1.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Polyethylene Glycol changes

Signature read: death-coded report count at 16 is the most distinctive stamp on Polyethylene Glycol's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
80
Total Reports
16
Deaths Reported
20.0%
Death-coded share of reports

Active Ingredients

Polyethylene Glycol

Administration Routes

UnknownOral

Species Affected

Cat 72
Dog 6
Human 2

Most Affected Breeds

Domestic Shorthair 49
Cat (unknown) 7
Domestic Longhair 6
Domestic Mediumhair 2
Unknown 2
Maine Coon 2
Siamese 2
Terrier - Bull - American Pit 2
Retriever - Labrador 1
Shepherd Dog - German 1

Most Reported Reactions

Vomiting 16
Not eating 15
Death by euthanasia 14
Lack of efficacy - NOS 13
Constipation 12
Diarrhoea 11
Weight loss 11
Behavioural disorder NOS 9
Ataxia 9
Lethargy (see also Central nervous system depression in Neurological) 9
Dehydration 8
Elevated blood urea nitrogen (BUN) 7

Outcome Breakdown

Ongoing
34 (42.5%)
Recovered/Normal
16 (20.0%)
Euthanized
14 (17.5%)
Outcome Unknown
13 (16.3%)
Died
2 (2.5%)
Recovered with Sequela
1 (1.3%)

Polyethylene Glycol: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Polyethylene Glycol, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (20.0% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Polyethylene Glycol (#874 of 2,679 by report volume); death-coded 20.0%. PlainBreed drug row · death-coded report count stamp 16 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →