Drug profile

The FDA adverse-event record for Eprinomectin 0.4% W/V / Esafoxolaner 1.2% W/V / Praziquantel 8.3% W/V Solution

Name: Eprinomectin 0.4% W/V / Esafoxolaner 1.2% W/V / Praziquantel 8.3% W/V Solution - FDA Animal Adverse Event Reports
Creator: PlainBreed
License: https://creativecommons.org/publicdomain/zero/1.0/

80 FDA reports name Eprinomectin 0.4% W/V / Esafoxolaner 1.2% W/V / Praziquantel 8.3% W/V Solution, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#873 of 2,679
by report volume (all drugs): 80
adverse-event reports: 17.5%
death-coded share: Cat
most-reported species

Compiled by PlainBreed

Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Eprinomectin 0.4% W/V / Esafoxolaner 1.2% W/V / Praziquantel 8.3% W/V Solution ranks #871 of 2679 by total reports (80) and #286 of 1130 by death-coded share (17.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1): 97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1): #871
This drug, reports of 2679: #286
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Eprinomectin 0.4% W/V / Esafoxolaner 1.2% W/V / Praziquantel 8.3% W/V Solution has 80 reports now versus 80 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Eprinomectin 0.4% W/V / Esafoxolaner 1.2% W/V / Praziquantel 8.3% W/V Solution changes

Signature read: death-coded report count at 14 is the most distinctive stamp on Eprinomectin 0.4% W/V / Esafoxolaner 1.2% W/V / Praziquantel 8.3% W/V Solution's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

17.5%

Death-coded share of reports

Active Ingredients

Eprinomectin 0.4% W/V / Esafoxolaner 1.2% W/V / Praziquantel 8.3% W/V Solution

Administration Routes

TopicalUnknownOralSubcutaneous

Species Affected

Cat 79

Dog 1

Most Affected Breeds

Domestic Shorthair 63

Domestic Mediumhair 7

Domestic Longhair 4

Cat (other) 2

Chihuahua 1

Persian 1

Maine Coon 1

Cat (unknown) 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in Neurological) 18

Seizure NOS 9

Ataxia 9

Application site hair loss 8

Lack of efficacy (ectoparasite) - flea 8

Death 8

Vomiting 7

Tremor 6

Not eating 6

Death by euthanasia 6

Hiding 5

Twitching 5

Outcome Breakdown

Outcome Unknown

33 (41.3%)

Ongoing

18 (22.5%)

Recovered/Normal

15 (18.8%)

Died

8 (10.0%)

Euthanized

6 (7.5%)

Eprinomectin 0.4% W/V / Esafoxolaner 1.2% W/V / Praziquantel 8.3% W/V Solution: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Eprinomectin 0.4% W/V / Esafoxolaner 1.2% W/V / Praziquantel 8.3% W/V Solution, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (80 here).

Amprolium Ion 80 Blood Transfusion 80 Polyethylene Glycol 80 Unspecified Thyroid Medication 80

Similar death-coded share

Nearest other drugs by death-coded share (17.5% here), distinct from the volume row.

Deracoxib 17.5% Canine Infl H3N2 / H3N8 Kv 17.5% Doramectin 17.4% Amoxicillin/Clavulanic Acid 17.6%

What to do with this drug

Compare Eprinomectin 0.4% W/V / Esafoxolaner 1.2% W/V / Praziquantel 8.3% W/V Solution's report volume and death-coded share against similar drugs nationwide. See similar drugs
Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Eprinomectin 0.4% W/V / Esafoxolaner 1.2% W/V / Praziquantel 8.3% W/V Solution (#873 of 2,679 by report volume); death-coded 17.5%. PlainBreed drug row · death-coded report count stamp 14 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →