Ampicillin Sodium/Sulbactam Sodium

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138 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
138
Total Reports
47
Deaths Reported
3410.0%
Death Rate

Active Ingredients

Ampicillin Sodium/Sulbactam Sodium

Administration Routes

UnknownIntravenousParenteralOther

Species Affected

Dog 89
Cat 49

Most Affected Breeds

Domestic Shorthair 27
Retriever - Labrador 19
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) 7
Domestic Mediumhair 6
Retriever - Golden 5
Domestic Longhair 4
Spitz - German Pomeranian 4
Poodle (unspecified) 4
Pit Bull 3
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 3

Most Reported Reactions

Other abnormal test result NOS 38
Not eating 33
Death by euthanasia 31
Vomiting 30
Lethargy (see also Central nervous system depression in Neurological) 28
Elevated alanine aminotransferase (ALT) 26
Diarrhoea 21
Anorexia 20
Elevated total bilirubin 20
Dehydration 19
Abnormal ultrasound finding 19
Leucocytosis NOS 17

Outcome Breakdown

Outcome Unknown
37 (26.6%)
Ongoing
35 (25.2%)
Euthanized
31 (22.3%)
Recovered/Normal
20 (14.4%)
Died
16 (11.5%)

Data Summary

Metric Value
Total adverse event reports 138
Reports involving death 47
Case-fatality rate (reported events) 3410.0%
Distinct species in reports 2
Distinct breeds in reports 20
Distinct reactions reported 20
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Ampicillin Sodium/Sulbactam Sodium Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 138 adverse event reports referencing Ampicillin Sodium/Sulbactam Sodium, including 47 reports in which the animal died — a 3410.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Ampicillin Sodium/Sulbactam Sodium. Reported administration routes include Unknown, Intravenous, Parenteral, Other. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Ampicillin Sodium/Sulbactam Sodium reports are Dog (89 reports), Cat (49 reports), with Dog accounting for the largest share. Within those species, Domestic Shorthair (27), Retriever - Labrador (19), Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) (7) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Ampicillin Sodium/Sulbactam Sodium are Other abnormal test result NOS (38), Not eating (33), Death by euthanasia (31), Vomiting (30). Of the 139 reports with a coded outcome, Outcome Unknown is the leading category at 26.6%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Ampicillin Sodium/Sulbactam Sodium.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial