Drug profile

The FDA adverse-event record for Benazepril Hydrochloride

105 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Benazepril Hydrochloride. See the species affected, top reactions, and outcomes below.

105
adverse-event reports
21.9%
death-coded share
Dog
most-reported species
20
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
105
Total Reports
23
Deaths Reported
21.9%
Death Rate

Active Ingredients

Benazepril Hydrochloride

Administration Routes

UnknownOral

Species Affected

Dog 95
Cat 10

Most Affected Breeds

Retriever - Labrador 8
Shih Tzu 7
Retriever - Golden 7
Maltese 6
Terrier - Yorkshire 6
Chihuahua 5
Terrier (unspecified) 4
Mixed (Dog) 4
Domestic Shorthair 4
Dog (unknown) 4

Most Reported Reactions

Vomiting 20
Anorexia 17
Lethargy (see also Central nervous system depression in 'Neurological') 17
Lack of efficacy - NOS 14
Other abnormal test result NOS 14
Diarrhoea 14
Death by euthanasia 13
Elevated blood urea nitrogen (BUN) 12
Elevated serum alkaline phosphatase (SAP) 12
Abnormal ultrasound finding 11
Decreased appetite 10
Elevated creatinine 10

Outcome Breakdown

Ongoing
52 (49.1%)
Outcome Unknown
16 (15.1%)
Recovered/Normal
14 (13.2%)
Euthanized
12 (11.3%)
Died
11 (10.4%)
Recovered with Sequela
1 (0.9%)

Benazepril Hydrochloride Adverse Event Insights

105 reports name Benazepril Hydrochloride; 23 recorded a death outcome (21.9% of reported events, not a population-level mortality rate). Active ingredient: Benazepril Hydrochloride. Administration routes: Unknown, Oral.

By species: Dog (95 reports), Cat (10 reports). By breed: Retriever - Labrador (8), Shih Tzu (7), Retriever - Golden (7).

Leading clinical signs: Vomiting (20), Anorexia (17), Lethargy (see also Central nervous system depression in 'Neurological') (17), Lack of efficacy - NOS (14). Outcome, 106 coded reports: Ongoing leads at 49.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.