Drug profile

The FDA adverse-event record for Morphine

365 FDA reports name Morphine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#371 of 2,679
by report volume (all drugs)
365
adverse-event reports
20.8%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Morphine ranks #371 of 2679 by total reports (365) and #231 of 1130 by death-coded share (20.8%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#371
This drug, reports of 2679
#231
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Morphine has 365 reports now versus 365 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Morphine changes

Signature read: death-coded report count at 76 is the most distinctive stamp on Morphine's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
365
Total Reports
76
Deaths Reported
20.8%
Death-coded share of reports

Active Ingredients

Morphine

Administration Routes

UnknownIntramuscularSubcutaneousIntravenousParenteralEpiduralOral

Species Affected

Dog 289
Cat 58
Horse 7
Human 3
Goat 2
Pig 2
Other 2
Donkey 1
Cattle 1

Most Affected Breeds

Retriever - Labrador 52
Domestic Shorthair 35
Dog (unknown) 29
Boxer (German Boxer) 14
Crossbred Canine/dog 14
Retriever - Golden 11
Dachshund (unspecified) 10
Chihuahua 9
Mixed (Dog) 8
Terrier - Yorkshire 8

Most Reported Reactions

Vomiting 54
Other abnormal test result NOS 49
Lethargy (see also Central nervous system depression in 'Neurological') 42
Death 40
Anorexia 37
Death by euthanasia 36
Lack of efficacy - NOS 35
Bradycardia 27
Pain NOS 20
Elevated alanine aminotransferase (ALT) 20
Weight loss 20
Diarrhoea 20

Outcome Breakdown

Recovered/Normal
150 (41.4%)
Ongoing
71 (19.6%)
Outcome Unknown
59 (16.3%)
Died
39 (10.8%)
Euthanized
38 (10.5%)
Recovered with Sequela
5 (1.4%)

Morphine: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Morphine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (365 here).

Similar death-coded share

Nearest other drugs by death-coded share (20.8% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Morphine (#371 of 2,679 by report volume); death-coded 20.8%. PlainBreed drug row · death-coded report count stamp 76 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →