Drug profile

The FDA adverse-event record for Morphine

349 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Morphine. See the species affected, top reactions, and outcomes below.

349
adverse-event reports
20.6%
death-coded share
Dog
most-reported species
54
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
349
Total Reports
72
Deaths Reported
20.6%
Death Rate

Active Ingredients

Morphine

Administration Routes

UnknownIntramuscularSubcutaneousIntravenousParenteralEpiduralOral

Species Affected

Dog 276
Cat 57
Horse 6
Human 3
Pig 2
Goat 2
Donkey 1
Other 1
Cattle 1

Most Affected Breeds

Retriever - Labrador 50
Domestic Shorthair 35
Dog (unknown) 25
Boxer (German Boxer) 14
Crossbred Canine/dog 14
Retriever - Golden 11
Dachshund (unspecified) 10
Chihuahua 9
Terrier - Yorkshire 8
Shih Tzu 8

Most Reported Reactions

Vomiting 54
Other abnormal test result NOS 48
Lethargy (see also Central nervous system depression in 'Neurological') 42
Death 38
Anorexia 37
Death by euthanasia 34
Lack of efficacy - NOS 32
Bradycardia 24
Elevated alanine aminotransferase (ALT) 20
Weight loss 20
Seizure NOS 20
Not eating 20

Outcome Breakdown

Recovered/Normal
141 (40.8%)
Ongoing
70 (20.2%)
Outcome Unknown
57 (16.5%)
Died
37 (10.7%)
Euthanized
36 (10.4%)
Recovered with Sequela
5 (1.4%)

Morphine Adverse Event Insights

349 reports name Morphine; 72 recorded a death outcome (20.6% of reported events, not a population-level mortality rate). Active ingredient: Morphine. Administration routes: Unknown, Intramuscular, Subcutaneous, Intravenous.

By species: Dog (276 reports), Cat (57 reports), Horse (6 reports). By breed: Retriever - Labrador (50), Domestic Shorthair (35), Dog (unknown) (25).

Leading clinical signs: Vomiting (54), Other abnormal test result NOS (48), Lethargy (see also Central nervous system depression in 'Neurological') (42), Death (38). Outcome, 346 coded reports: Recovered/Normal leads at 40.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.