Spironolactone

165 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

165

Total Reports

Deaths Reported

1820.0%

Death Rate

Active Ingredients

Spironolactone

Administration Routes

OralUnknownRectal

Species Affected

Dog 147

Cat 15

Human 3

Most Affected Breeds

Chihuahua 18

Maltese 13

Domestic Shorthair 13

Shih Tzu 8

Spitz - German Pomeranian 8

Crossbred Canine/dog 8

Spaniel - King Charles Cavalier 6

Terrier (unspecified) 6

Shepherd Dog - Australian 6

Schnauzer - Miniature 5

Most Reported Reactions

Vomiting 37

Lethargy (see also Central nervous system depression in 'Neurological') 27

Diarrhoea 25

Elevated blood urea nitrogen (BUN) 23

Death by euthanasia 19

Anorexia 19

Decreased appetite 18

Elevated creatinine 17

Weight loss 15

Lack of efficacy - NOS 15

Elevated alanine aminotransferase (ALT) 14

Death 12

Outcome Breakdown

Ongoing

51 (30.7%)

Outcome Unknown

50 (30.1%)

Recovered/Normal

31 (18.7%)

Euthanized

18 (10.8%)

Died

12 (7.2%)

Recovered with Sequela

4 (2.4%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.