Drug profile

The FDA adverse-event record for Estradiol, Trenbolone Acetate

134 FDA reports name Estradiol, Trenbolone Acetate, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#669 of 2,679
by report volume (all drugs)
134
adverse-event reports
20.9%
death-coded share
Cattle
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Estradiol, Trenbolone Acetate ranks #667 of 2679 by total reports (134) and #229 of 1130 by death-coded share (20.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#667
This drug, reports of 2679
#229
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Estradiol, Trenbolone Acetate has 134 reports now versus 134 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Estradiol, Trenbolone Acetate changes

Signature read: death-coded report count at 28 is the most distinctive stamp on Estradiol, Trenbolone Acetate's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
134
Total Reports
28
Deaths Reported
20.9%
Death-coded share of reports

Active Ingredients

Estradiol, Trenbolone Acetate

Administration Routes

UnknownSubcutaneousOral

Species Affected

Cattle 77
Unknown 55
Human 1
Dog 1

Most Affected Breeds

Unknown 56
Cattle (unknown) 28
Crossbred Bovine/Cattle 18
Holstein-Friesian also known as Holstein 13
Aberdeen Angus 12
Mixed (Cattle) 2
Beefmaster 2
Cattle (other) 1
Cattle (unspecified) 1
Dog (other) 1

Most Reported Reactions

Death 26
Increased sexual interest 24
Implant, Abnormal 23
Underfilling, Package 14
Color, Abnormal 13
Anaphylaxis 11
Dispenser, Abnormal 11
Behavioural disorder NOS 7
INEFFECTIVE, WEIGHT INC 5
Recumbency 4
Caps, Abnormal 4
Collapse (see also 'Cardio-vascular' and 'Systemic disorders') 4

Outcome Breakdown

Died
28 (84.8%)
Outcome Unknown
3 (9.1%)
Ongoing
1 (3.0%)
Recovered/Normal
1 (3.0%)

Estradiol, Trenbolone Acetate: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Estradiol, Trenbolone Acetate, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Estradiol, Trenbolone Acetate's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Estradiol, Trenbolone Acetate (#669 of 2,679 by report volume); death-coded 20.9%. PlainBreed drug row · death-coded report count stamp 28 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →