Drug profile

The FDA adverse-event record for Estradiol, Trenbolone Acetate

134 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Estradiol, Trenbolone Acetate. See the species affected, top reactions, and outcomes below.

134
adverse-event reports
20.9%
death-coded share
Cattle
most-reported species
26
Death - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
134
Total Reports
28
Deaths Reported
20.9%
Death Rate

Active Ingredients

Estradiol, Trenbolone Acetate

Administration Routes

UnknownSubcutaneousOral

Species Affected

Cattle 77
Unknown 55
Human 1
Dog 1

Most Affected Breeds

Unknown 56
Cattle (unknown) 28
Crossbred Bovine/Cattle 18
Holstein-Friesian also known as Holstein 13
Aberdeen Angus 12
Mixed (Cattle) 2
Beefmaster 2
Cattle (other) 1
Cattle (unspecified) 1
Dog (other) 1

Most Reported Reactions

Death 26
Increased sexual interest 24
Implant, Abnormal 23
Underfilling, Package 14
Color, Abnormal 13
Anaphylaxis 11
Dispenser, Abnormal 11
Behavioural disorder NOS 7
INEFFECTIVE, WEIGHT INC 5
Caps, Abnormal 4
Recumbency 4
Collapse (see also 'Cardio-vascular' and 'Systemic disorders') 4

Outcome Breakdown

Died
28 (84.8%)
Outcome Unknown
3 (9.1%)
Ongoing
1 (3.0%)
Recovered/Normal
1 (3.0%)

Estradiol, Trenbolone Acetate Adverse Event Insights

134 reports name Estradiol, Trenbolone Acetate; 28 recorded a death outcome (20.9% of reported events, not a population-level mortality rate). Active ingredient: Estradiol, Trenbolone Acetate. Administration routes: Unknown, Subcutaneous, Oral.

By species: Cattle (77 reports), Unknown (55 reports), Human (1 reports). By breed: Unknown (56), Cattle (unknown) (28), Crossbred Bovine/Cattle (18).

Leading clinical signs: Death (26), Increased sexual interest (24), Implant, Abnormal (23), Underfilling, Package (14). Outcome, 33 coded reports: Died leads at 84.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.