Melatonin
236 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
236
Total Reports
29
Deaths Reported
1230.0%
Death Rate
Active Ingredients
Melatonin
Administration Routes
OralUnknownSubcutaneous
Species Affected
Dog 231
Cat 2
Human 2
Pig 1
Most Affected Breeds
Retriever - Labrador 28
Boxer (German Boxer) 14
Shih Tzu 10
Spitz - German Pomeranian 9
Crossbred Canine/dog 8
Chihuahua 7
Maltese 7
Dachshund (unspecified) 7
Shepherd Dog - German 6
Bulldog 6
Most Reported Reactions
Diarrhoea 35
Vomiting 32
Lethargy (see also Central nervous system depression in 'Neurological') 28
Decreased appetite 23
Polydipsia 22
Death by euthanasia 21
Polyuria 20
Weight loss 20
Other abnormal test result NOS 20
Anorexia 20
Elevated alanine aminotransferase (ALT) 18
Emesis 17
Outcome Breakdown
Ongoing
80 (33.9%)
Outcome Unknown
66 (28.0%)
Recovered/Normal
59 (25.0%)
Euthanized
20 (8.5%)
Died
9 (3.8%)
Recovered with Sequela
2 (0.8%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.