Drug profile

The FDA adverse-event record for Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate)

255 FDA reports name Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate), a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#470 of 2,679
by report volume (all drugs)
255
adverse-event reports
3.9%
death-coded share
Unknown
most-reported species
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Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) ranks #470 of 2679 by total reports (255) and #853 of 1130 by death-coded share (3.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#470
This drug, reports of 2679
#853
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) has 255 reports now versus 255 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) changes

Signature read: 255 reports place Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) in the upper third of FDA AER volume (#470 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
255
Total Reports
10
Deaths Reported
3.9%
Death-coded share of reports

Active Ingredients

Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate)

Administration Routes

UnknownOralOphthalmic

Species Affected

Unknown 168
Dog 58
Cat 27
Rabbit 1
Human 1

Most Affected Breeds

Unknown 169
Domestic Shorthair 19
Retriever - Labrador 7
Retriever - Golden 5
Dachshund (unspecified) 3
Spitz - German Pomeranian 2
Shepherd Dog - Australian 2
Pug 2
Beagle 2
Chihuahua 2

Most Reported Reactions

Color, Abnormal 158
Suspension, Abnormal 120
Uncoded sign 43
Lack of efficacy (bacteria) - NOS 21
Lethargy (see also Central nervous system depression in 'Neurological') 19
Vomiting 18
Other abnormal test result NOS 13
Anorexia 12
Leucocytosis NOS 11
Lack of efficacy - NOS 10
Ataxia 10
Emesis 10

Outcome Breakdown

Ongoing
53 (60.9%)
Recovered/Normal
14 (16.1%)
Outcome Unknown
9 (10.3%)
Euthanized
6 (6.9%)
Died
4 (4.6%)
Recovered with Sequela
1 (1.1%)

Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate): low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate), both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (3.9% here), distinct from the volume row.

Device: Endotracheal Tube 3.9% Sarolaner/Moxidectin/Pyrantel 3.9% Melarsomine Dihydrochloride 3.9% Cetirizine 3.9%

What to do with this drug

  • Compare Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate)'s report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) (#470 of 2,679 by report volume); death-coded 3.9%. PlainBreed drug row · report volume stamp 255 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →