Drug profile

The FDA adverse-event record for Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate)

255 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate). See the species affected, top reactions, and outcomes below.

255
adverse-event reports
3.9%
death-coded share
Unknown
most-reported species
158
Color, Abnormal - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
255
Total Reports
10
Deaths Reported
3.9%
Death Rate

Active Ingredients

Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate)

Administration Routes

UnknownOralOphthalmic

Species Affected

Unknown 168
Dog 58
Cat 27
Rabbit 1
Human 1

Most Affected Breeds

Unknown 169
Domestic Shorthair 19
Retriever - Labrador 7
Retriever - Golden 5
Dachshund (unspecified) 3
Spitz - German Pomeranian 2
Shepherd Dog - Australian 2
Pug 2
Beagle 2
Chihuahua 2

Most Reported Reactions

Color, Abnormal 158
Suspension, Abnormal 120
Uncoded sign 43
Lack of efficacy (bacteria) - NOS 21
Lethargy (see also Central nervous system depression in 'Neurological') 19
Vomiting 18
Other abnormal test result NOS 13
Anorexia 12
Leucocytosis NOS 11
Ataxia 10
Lack of efficacy - NOS 10
Seal, Abnormal 10

Outcome Breakdown

Ongoing
53 (60.9%)
Recovered/Normal
14 (16.1%)
Outcome Unknown
9 (10.3%)
Euthanized
6 (6.9%)
Died
4 (4.6%)
Recovered with Sequela
1 (1.1%)

Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) Adverse Event Insights

255 reports name Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate); 10 recorded a death outcome (3.9% of reported events, not a population-level mortality rate). Active ingredient: Amoxicillin As Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate). Administration routes: Unknown, Oral, Ophthalmic.

By species: Unknown (168 reports), Dog (58 reports), Cat (27 reports). By breed: Unknown (169), Domestic Shorthair (19), Retriever - Labrador (7).

Leading clinical signs: Color, Abnormal (158), Suspension, Abnormal (120), Uncoded sign (43), Lack of efficacy (bacteria) - NOS (21). Outcome, 87 coded reports: Ongoing leads at 60.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.