Drug profile

The FDA adverse-event record for Liver Supplement

116 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Liver Supplement. See the species affected, top reactions, and outcomes below.

116
adverse-event reports
7.8%
death-coded share
Dog
most-reported species
23
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
116
Total Reports
9
Deaths Reported
7.8%
Death Rate

Active Ingredients

Liver Supplement

Administration Routes

OralUnknownOther

Species Affected

Dog 106
Cat 9
Horse 1

Most Affected Breeds

Retriever - Labrador 10
Chihuahua 7
Dog (unknown) 7
Crossbred Canine/dog 7
Terrier (unspecified) 6
Shepherd Dog - German 5
Domestic Shorthair 4
Spaniel - Springer English 4
Spitz - German Pomeranian 3
Poodle - Toy 3

Most Reported Reactions

Vomiting 23
Diarrhoea 22
Elevated alanine aminotransferase (ALT) 19
Lethargy (see also Central nervous system depression in Neurological) 16
Not eating 13
Lack of efficacy - NOS 11
Behavioural disorder NOS 11
Weight loss 10
Decreased appetite 10
Elevated gamma-glutamyl transferase (GGT) 10
Emesis 9
Lethargy (see also Central nervous system depression in 'Neurological') 9

Outcome Breakdown

Outcome Unknown
42 (35.9%)
Ongoing
34 (29.1%)
Recovered/Normal
28 (23.9%)
Euthanized
7 (6.0%)
Recovered with Sequela
4 (3.4%)
Died
2 (1.7%)

Liver Supplement Adverse Event Insights

116 reports name Liver Supplement; 9 recorded a death outcome (7.8% of reported events, not a population-level mortality rate). Active ingredient: Liver Supplement. Administration routes: Oral, Unknown, Other.

By species: Dog (106 reports), Cat (9 reports), Horse (1 reports). By breed: Retriever - Labrador (10), Chihuahua (7), Dog (unknown) (7).

Leading clinical signs: Vomiting (23), Diarrhoea (22), Elevated alanine aminotransferase (ALT) (19), Lethargy (see also Central nervous system depression in Neurological) (16). Outcome, 117 coded reports: Outcome Unknown leads at 35.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.