Drug profile

The FDA adverse-event record for Flea Spray (Unknown)

95 FDA reports name Flea Spray (Unknown), a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#799 of 2,679
by report volume (all drugs)
95
adverse-event reports
1.1%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Flea Spray (Unknown) ranks #797 of 2679 by total reports (95) and #1067 of 1130 by death-coded share (1.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#797
This drug, reports of 2679
#1067
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Flea Spray (Unknown) has 95 reports now versus 93 in that prior snapshot: 2 more (2.2%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Flea Spray (Unknown) changes

Signature read: Flea Spray (Unknown)'s 1.1% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
95
Total Reports
1
Deaths Reported
1.1%
Death-coded share of reports

Active Ingredients

Flea Spray (Unknown)

Administration Routes

OtherTopicalUnknownCutaneous

Species Affected

Dog 69
Cat 26

Most Affected Breeds

Domestic Shorthair 11
Terrier - Jack Russell 6
Dog (unknown) 6
Cat (unknown) 6
Dachshund - Miniature 5
Retriever - Labrador 4
Chihuahua 4
Maine Coon 4
Crossbred Canine/dog 4
Terrier - Yorkshire 3

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 54
Lack of efficacy (flea) 22
Product label issues 7
Lethargy (see also Central nervous system depression in 'Neurological') 6
Vomiting 6
Drug dose administration interval too short 5
Lot # and/or Expiration date illegible 5
Behavioural disorder NOS 4
Overdose 4
Scratching 3
Panting 3
Walking difficulty 3

Outcome Breakdown

Outcome Unknown
66 (69.5%)
Ongoing
22 (23.2%)
Recovered/Normal
6 (6.3%)
Died
1 (1.1%)

Flea Spray (Unknown): low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Flea Spray (Unknown), both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Flea Spray (Unknown) (#799 of 2,679 by report volume); death-coded 1.1%. PlainBreed drug row · death-coded share stamp 1.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →