Lufenuron + Milbemycin Oxime + Praziquantel
2,444 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
2,444
Total Reports
26
Deaths Reported
110.0%
Death Rate
Active Ingredients
LufenuronMilbemycin OximePraziquantel
Administration Routes
OralUnknownOphthalmicRespiratory (Inhalation)
Species Affected
Dog 2,296
Unknown 146
Human 2
Most Affected Breeds
Retriever - Labrador 425
Unknown 148
Dog (unknown) 138
Retriever - Golden 126
Shepherd Dog - German 115
Crossbred Canine/dog 102
Pit Bull 83
Chihuahua 64
Beagle 63
Boxer (German Boxer) 57
Most Reported Reactions
INEFFECTIVE, HOOKS 528
Lack of efficacy (endoparasite) - heartworm 422
Vomiting 382
Lack of efficacy (heartworm) 199
Diarrhoea 176
Lethargy (see also Central nervous system depression in 'Neurological') 141
INEFFECTIVE, HEARTWORM LARVAE 137
Lack of efficacy (roundworm) 127
Product problem 123
Containers, Damaged 86
Lack of efficacy (endoparasite) - roundworm NOS 79
Underdose 72
Outcome Breakdown
Outcome Unknown
1,659 (72.2%)
Recovered/Normal
578 (25.1%)
Ongoing
33 (1.4%)
Euthanized
13 (0.6%)
Died
13 (0.6%)
Recovered with Sequela
3 (0.1%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.