Fipronil + Pyriproxyfen + S-Methoprene

293 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

293

Total Reports

Deaths Reported

440.0%

Death Rate

Active Ingredients

FipronilPyriproxyfenS-Methoprene

Administration Routes

OtherTopicalUnknownOral

Species Affected

Dog 269

Cat 23

Human 1

Most Affected Breeds

Retriever - Labrador 30

Retriever - Golden 20

Shepherd Dog - German 15

Domestic Shorthair 14

Shih Tzu 12

Chihuahua 12

Crossbred Canine/dog 11

Collie - Border 9

Beagle 8

Dog (unknown) 7

Most Reported Reactions

Vomiting 43

Lethargy (see also Central nervous system depression in 'Neurological') 39

Lack of efficacy (ectoparasite) - flea 37

Seizure NOS 29

Lack of efficacy (bacteria) - NOS 23

Diarrhoea 22

Lack of efficacy (tick) 21

Lack of efficacy (bacteria) - Borrelia 16

Anorexia 14

Shaking 13

Ataxia 11

Not eating 11

Outcome Breakdown

Outcome Unknown

170 (58.0%)

Recovered/Normal

87 (29.7%)

Ongoing

23 (7.8%)

Euthanized

7 (2.4%)

Died

6 (2.0%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.