Drug profile

The FDA adverse-event record for Milbemycin Oxime/Praziquantel

120 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Milbemycin Oxime/Praziquantel. See the species affected, top reactions, and outcomes below.

120
adverse-event reports
5.0%
death-coded share
Dog
most-reported species
22
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
120
Total Reports
6
Deaths Reported
5.0%
Death Rate

Active Ingredients

Milbemycin Oxime/Praziquantel

Administration Routes

OralUnknown

Species Affected

Dog 120

Most Affected Breeds

Crossbred Canine/dog 13
Retriever - Labrador 13
Shepherd Dog - German 6
Terrier - Yorkshire 5
Chihuahua 5
Retriever - Golden 5
Shepherd Dog - Australian 4
Maltese 3
Dog (unknown) 3
Beagle 3

Most Reported Reactions

Vomiting 22
Lack of efficacy (endoparasite) - heartworm 17
Diarrhoea 14
Lethargy (see also Central nervous system depression in 'Neurological') 13
Lack of efficacy (endoparasite) - tapeworm 10
Seizure NOS 7
Weight loss 7
Other abnormal test result NOS 6
Lack of efficacy (heartworm) 6
INEFFECTIVE, HEARTWORM LARVAE 5
Reluctant to move 5
Behavioural disorder NOS 4

Outcome Breakdown

Outcome Unknown
47 (39.2%)
Recovered/Normal
44 (36.7%)
Ongoing
22 (18.3%)
Died
3 (2.5%)
Euthanized
3 (2.5%)
Recovered with Sequela
1 (0.8%)

Milbemycin Oxime/Praziquantel Adverse Event Insights

120 reports name Milbemycin Oxime/Praziquantel; 6 recorded a death outcome (5.0% of reported events, not a population-level mortality rate). Active ingredient: Milbemycin Oxime/Praziquantel. Administration routes: Oral, Unknown.

By species: Dog (120 reports). By breed: Crossbred Canine/dog (13), Retriever - Labrador (13), Shepherd Dog - German (6).

Leading clinical signs: Vomiting (22), Lack of efficacy (endoparasite) - heartworm (17), Diarrhoea (14), Lethargy (see also Central nervous system depression in 'Neurological') (13). Outcome, 120 coded reports: Outcome Unknown leads at 39.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.