Drug profile

The FDA adverse-event record for Da2Ppv+L*4 (Orig S-P Us) Lv+Kb

248 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Da2Ppv+L*4 (Orig S-P Us) Lv+Kb. See the species affected, top reactions, and outcomes below.

248
adverse-event reports
13.7%
death-coded share
Dog
most-reported species
70
Vomiting - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
248
Total Reports
34
Deaths Reported
13.7%
Death Rate

Active Ingredients

Da2Ppv+L*4 (Orig S-P Us) Lv+Kb

Administration Routes

SubcutaneousUnknownSubconjunctivalOther

Species Affected

Dog 247
Human 1

Most Affected Breeds

Crossbred Canine/dog 68
Shepherd Dog - German 13
Terrier (unspecified) 12
Retriever - Golden 10
Retriever - Labrador 9
Shih Tzu 8
Pit Bull 8
Siberian Husky 7
Boxer (German Boxer) 7
Terrier - Yorkshire 6

Most Reported Reactions

Vomiting 70
Emesis (multiple) 49
Lethargy (see also Central nervous system depression in 'Neurological') 44
Diarrhoea 27
Seizure NOS 24
Death 20
Fever 19
Leucocytosis NOS 17
Other abnormal test result NOS 14
Death by euthanasia 14
Anorexia 13
Shaking 13

Outcome Breakdown

Recovered/Normal
101 (40.6%)
Ongoing
87 (34.9%)
Outcome Unknown
23 (9.2%)
Died
20 (8.0%)
Euthanized
14 (5.6%)
Recovered with Sequela
4 (1.6%)

Da2Ppv+L*4 (Orig S-P Us) Lv+Kb Adverse Event Insights

248 reports name Da2Ppv+L*4 (Orig S-P Us) Lv+Kb; 34 recorded a death outcome (13.7% of reported events, not a population-level mortality rate). Active ingredient: Da2Ppv+L*4 (Orig S-P Us) Lv+Kb. Administration routes: Subcutaneous, Unknown, Subconjunctival, Other.

By species: Dog (247 reports), Human (1 reports). By breed: Crossbred Canine/dog (68), Shepherd Dog - German (13), Terrier (unspecified) (12).

Leading clinical signs: Vomiting (70), Emesis (multiple) (49), Lethargy (see also Central nervous system depression in 'Neurological') (44), Diarrhoea (27). Outcome, 249 coded reports: Recovered/Normal leads at 40.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.