Drug profile

The FDA adverse-event record for Enalapril

1,103 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Enalapril. See the species affected, top reactions, and outcomes below.

1,103
adverse-event reports
17.3%
death-coded share
Dog
most-reported species
143
Diarrhoea - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,103
Total Reports
191
Deaths Reported
17.3%
Death Rate

Active Ingredients

Enalapril

Administration Routes

OralUnknownVaginal

Species Affected

Dog 930
Unknown 126
Cat 46
Human 1

Most Affected Breeds

Unknown 130
Chihuahua 104
Maltese 55
Retriever - Labrador 50
Terrier - Yorkshire 48
Shih Tzu 36
Spaniel - King Charles Cavalier 35
Crossbred Canine/dog 35
Beagle 34
Spitz - German Pomeranian 33

Most Reported Reactions

Diarrhoea 143
Vomiting 142
Lethargy (see also Central nervous system depression in 'Neurological') 141
Death by euthanasia 127
Anorexia 90
Seizure NOS 88
Containers, Damaged 85
Elevated blood urea nitrogen (BUN) 81
Weight loss 72
Decreased appetite 68
Ataxia 63
Elevated alanine aminotransferase (ALT) 63

Outcome Breakdown

Outcome Unknown
292 (30.2%)
Ongoing
269 (27.8%)
Recovered/Normal
209 (21.6%)
Euthanized
123 (12.7%)
Died
68 (7.0%)
Recovered with Sequela
7 (0.7%)

Enalapril Adverse Event Insights

1,103 reports name Enalapril; 191 recorded a death outcome (17.3% of reported events, not a population-level mortality rate). Active ingredient: Enalapril. Administration routes: Oral, Unknown, Vaginal.

By species: Dog (930 reports), Unknown (126 reports), Cat (46 reports). By breed: Unknown (130), Chihuahua (104), Maltese (55).

Leading clinical signs: Diarrhoea (143), Vomiting (142), Lethargy (see also Central nervous system depression in 'Neurological') (141), Death by euthanasia (127). Outcome, 968 coded reports: Outcome Unknown leads at 30.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.