Drug profile

The FDA adverse-event record for Distemper Vaccine

1,141 FDA reports name Distemper Vaccine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#164 of 2,679
by report volume (all drugs)
1,141
adverse-event reports
8.2%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Distemper Vaccine ranks #164 of 2679 by total reports (1,141) and #633 of 1130 by death-coded share (8.2%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#164
This drug, reports of 2679
#633
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Distemper Vaccine has 1,141 reports now versus 1,130 in that prior snapshot: 11 more (1.0%).

Report change
+11
Death-coded reports
+1
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Distemper Vaccine changes

Signature read: 1,141 reports place Distemper Vaccine in the upper third of FDA AER volume (#164 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,141
Total Reports
93
Deaths Reported
8.2%
Death-coded share of reports

Active Ingredients

Distemper Vaccine

Administration Routes

UnknownParenteralSubcutaneousOralOtherSubconjunctivalIntramuscularTopicalIntrauterineNasal

Species Affected

Dog 1,011
Cat 127
Unknown 3

Most Affected Breeds

Retriever - Labrador 119
Domestic Shorthair 92
Chihuahua 48
Shepherd Dog - German 46
Crossbred Canine/dog 44
Pit Bull 40
Retriever - Golden 39
Boxer (German Boxer) 38
Terrier - Yorkshire 34
Shih Tzu 32

Most Reported Reactions

Vomiting 366
Emesis 239
Lethargy (see also Central nervous system depression in 'Neurological') 200
Diarrhoea 117
Other abnormal test result NOS 87
Behavioural disorder NOS 72
Seizure NOS 68
Not eating 61
Anorexia 51
Ataxia 48
Decreased appetite 46
Death 46

Outcome Breakdown

Recovered/Normal
592 (52.0%)
Outcome Unknown
260 (22.8%)
Ongoing
139 (12.2%)
Recovered with Sequela
55 (4.8%)
Died
55 (4.8%)
Euthanized
38 (3.3%)

Distemper Vaccine: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Distemper Vaccine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (1,141 here).

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Distemper Vaccine (#164 of 2,679 by report volume); death-coded 8.2%. PlainBreed drug row · report volume stamp 1,141 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →