Drug profile

The FDA adverse-event record for Ciprofloxacin Hcl

88 FDA reports name Ciprofloxacin Hcl, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#830 of 2,679
by report volume (all drugs)
88
adverse-event reports
21.6%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Ciprofloxacin Hcl ranks #827 of 2679 by total reports (88) and #212 of 1130 by death-coded share (21.6%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#827
This drug, reports of 2679
#212
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Ciprofloxacin Hcl has 88 reports now versus 88 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Ciprofloxacin Hcl changes

Signature read: death-coded report count at 19 is the most distinctive stamp on Ciprofloxacin Hcl's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
88
Total Reports
19
Deaths Reported
21.6%
Death-coded share of reports

Active Ingredients

Ciprofloxacin Hcl

Administration Routes

UnknownOralOphthalmicAuricular (Otic)

Species Affected

Dog 87
Cat 1

Most Affected Breeds

Retriever - Labrador 15
Retriever - Golden 6
Boxer (German Boxer) 6
Terrier - Bull - American Pit 5
Bulldog 4
Rottweiler 3
Spitz - German Pomeranian 2
Crossbred Canine/dog 2
Schnauzer - Miniature 2
Shepherd Dog - Australian 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 24
Other abnormal test result NOS 23
Vomiting 19
Death by euthanasia 16
Anorexia 14
Diarrhoea 12
Abnormal ultrasound finding 12
Elevated serum alkaline phosphatase (SAP) 12
Elevated alanine aminotransferase (ALT) 12
Leucocytosis NOS 11
Urinary tract infection 9
Elevated liver enzymes 9

Outcome Breakdown

Ongoing
56 (63.6%)
Euthanized
16 (18.2%)
Recovered/Normal
8 (9.1%)
Outcome Unknown
5 (5.7%)
Died
3 (3.4%)

Ciprofloxacin Hcl: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Ciprofloxacin Hcl, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (21.6% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Ciprofloxacin Hcl (#830 of 2,679 by report volume); death-coded 21.6%. PlainBreed drug row · death-coded report count stamp 19 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →