Drug profile

The FDA adverse-event record for Ciprofloxacin Hcl

88 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ciprofloxacin Hcl. See the species affected, top reactions, and outcomes below.

88
adverse-event reports
21.6%
death-coded share
Dog
most-reported species
24
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
88
Total Reports
19
Deaths Reported
21.6%
Death Rate

Active Ingredients

Ciprofloxacin Hcl

Administration Routes

UnknownOralOphthalmicAuricular (Otic)

Species Affected

Dog 87
Cat 1

Most Affected Breeds

Retriever - Labrador 15
Retriever - Golden 6
Boxer (German Boxer) 6
Terrier - Bull - American Pit 5
Bulldog 4
Rottweiler 3
Spitz - German Pomeranian 2
Crossbred Canine/dog 2
Schnauzer - Miniature 2
Shepherd Dog - Australian 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 24
Other abnormal test result NOS 23
Vomiting 19
Death by euthanasia 16
Anorexia 14
Diarrhoea 12
Abnormal ultrasound finding 12
Elevated serum alkaline phosphatase (SAP) 12
Elevated alanine aminotransferase (ALT) 12
Leucocytosis NOS 11
Urinary tract infection 9
Elevated liver enzymes 9

Outcome Breakdown

Ongoing
56 (63.6%)
Euthanized
16 (18.2%)
Recovered/Normal
8 (9.1%)
Outcome Unknown
5 (5.7%)
Died
3 (3.4%)

Ciprofloxacin Hcl Adverse Event Insights

88 reports name Ciprofloxacin Hcl; 19 recorded a death outcome (21.6% of reported events, not a population-level mortality rate). Active ingredient: Ciprofloxacin Hcl. Administration routes: Unknown, Oral, Ophthalmic, Auricular (Otic).

By species: Dog (87 reports), Cat (1 reports). By breed: Retriever - Labrador (15), Retriever - Golden (6), Boxer (German Boxer) (6).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (24), Other abnormal test result NOS (23), Vomiting (19), Death by euthanasia (16). Outcome, 88 coded reports: Ongoing leads at 63.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.