Drug profile

The FDA adverse-event record for Maropitant

2,016 FDA reports name Maropitant, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#113 of 2,679
by report volume (all drugs)
2,016
adverse-event reports
21.5%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Maropitant ranks #113 of 2679 by total reports (2,016) and #214 of 1130 by death-coded share (21.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#113
This drug, reports of 2679
#214
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Maropitant has 2,016 reports now versus 1,963 in that prior snapshot: 53 more (2.7%).

Report change
+53
Death-coded reports
+10
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Maropitant changes

Signature read: death-coded report count at 434 is the most distinctive stamp on Maropitant's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
2,016
Total Reports
434
Deaths Reported
21.5%
Death-coded share of reports

Active Ingredients

Maropitant

Administration Routes

SubcutaneousOralUnknownIntravenousParenteralIntramuscularOphthalmicTopicalOtherRespiratory (Inhalation)

Species Affected

Dog 1,494
Cat 414
Unknown 84
Human 19
Other 3
Rabbit 2

Most Affected Breeds

Crossbred Canine/dog 174
Retriever - Labrador 163
Domestic Shorthair 161
Domestic (unspecified) 127
Unknown 117
Dog (unknown) 84
Retriever - Golden 61
Chihuahua 49
Terrier - Yorkshire 48
Shepherd Dog - German 46

Most Reported Reactions

Vomiting 292
Anorexia 234
Death by euthanasia 233
Diarrhoea 198
Death 195
INEFFECTIVE, ANTIEMETIC 159
Elevated alanine aminotransferase (ALT) 154
Depression 139
Weight loss 129
Lethargy (see also Central nervous system depression in Neurological) 127
Abnormal radiograph finding 123
Lethargy (see also Central nervous system depression in 'Neurological') 120

Outcome Breakdown

Recovered/Normal
325 (26.9%)
Died
288 (23.9%)
Outcome Unknown
241 (20.0%)
Ongoing
196 (16.2%)
Euthanized
148 (12.3%)
Recovered with Sequela
9 (0.7%)

Maropitant: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Maropitant, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (21.5% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Maropitant (#113 of 2,679 by report volume); death-coded 21.5%. PlainBreed drug row · death-coded report count stamp 434 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →