Drug profile

The FDA adverse-event record for Anesthetic (Unknown)

671 FDA reports name Anesthetic (Unknown), a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#246 of 2,679
by report volume (all drugs)
671
adverse-event reports
10.1%
death-coded share
Cat
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Anesthetic (Unknown) ranks #246 of 2679 by total reports (671) and #541 of 1130 by death-coded share (10.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#246
This drug, reports of 2679
#541
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Anesthetic (Unknown) has 671 reports now versus 662 in that prior snapshot: 9 more (1.4%).

Report change
+9
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Anesthetic (Unknown) changes

Signature read: 671 reports place Anesthetic (Unknown) in the upper third of FDA AER volume (#246 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
671
Total Reports
68
Deaths Reported
10.1%
Death-coded share of reports

Active Ingredients

Anesthetic (Unknown)

Administration Routes

UnknownParenteralIntravenousRespiratory (Inhalation)TopicalOtherIntramuscularOralNasalTransdermal

Species Affected

Cat 370
Dog 301

Most Affected Breeds

Domestic Shorthair 186
Cat (unknown) 95
Retriever - Labrador 31
Dog (unknown) 26
Domestic Longhair 19
Domestic Mediumhair 15
Shepherd Dog - German 14
Shih Tzu 13
Retriever - Golden 13
Boxer (German Boxer) 12

Most Reported Reactions

Vomiting 64
Not eating 64
Behavioural disorder NOS 57
Lethargy (see also Central nervous system depression in 'Neurological') 43
Lack of efficacy - NOS 39
Other abnormal test result NOS 38
Dilated pupils 38
Diarrhoea 38
Death by euthanasia 37
Decreased appetite 36
Dysphoria 36
Weight loss 32

Outcome Breakdown

Ongoing
199 (29.6%)
Recovered/Normal
197 (29.3%)
Outcome Unknown
195 (29.0%)
Euthanized
37 (5.5%)
Died
31 (4.6%)
Recovered with Sequela
13 (1.9%)

Anesthetic (Unknown): high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Anesthetic (Unknown), both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (671 here).

Similar death-coded share

Nearest other drugs by death-coded share (10.1% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Anesthetic (Unknown) (#246 of 2,679 by report volume); death-coded 10.1%. PlainBreed drug row · report volume stamp 671 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →