Reaction profile

The FDA adverse-event record for tubes, abnormal

1,153 FDA adverse-event reports reference tubes, abnormal (VeDDRA 99027). See the species, breeds, and drugs most associated with it below.

1,153
reports citing this reaction
0.0%
death-coded share
Unknown
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
1,153
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Unknown 1,095
Human 25
Cat 18
Dog 13
Rabbit 1
Cattle 1

Breeds Most Affected

Unknown 1,120
Domestic (unspecified) 5
Domestic Shorthair 5
Dog (unknown) 4
Cat (unknown) 4
Cat (other) 3
Spitz - German Pomeranian 2
Crossbred Canine/dog 2
Rabbit (unknown) 1
Dachshund (unspecified) 1

Associated Drugs

Selamectin 432
Selamectin;Sarolaner 175
Cyclosporine 91
Imidacloprid + Moxidectin 84
Cyclosporin Ointment 61
Cyclosporine A 43
Mirtazapine 43
Fluralaner Spot-On Solution 29
Betamethasone + Florfenicol + Terbinafine 21
Emodepside + Praziquantel 18
Cephapirin Sodium 12
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 12
Milbemycin Oxime Solution 11
Cephapirin Benzathine 10
Ivermectin 10
Imidacloprid, Moxidectin 8
Flunixin Meglumine 5
Ceftiofur Hydrochloride 5
Praziquantel; Moxidectin 5
Genta/Betamet/Clotrim Ear Oint 5

Tubes, Abnormal Reaction Insights

1,153 reports name Tubes, Abnormal; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 99027.

By species: Unknown (1,095 reports), Human (25 reports), Cat (18 reports). By breed: Unknown (1,120), Domestic (unspecified) (5), Domestic Shorthair (5).

Most co-reported drugs: Selamectin (432 reports), Selamectin;Sarolaner (175 reports), Cyclosporine (91 reports), Imidacloprid + Moxidectin (84 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.