Reaction profile

The FDA adverse-event record for leucocytosis nos

7,187 FDA adverse-event reports reference leucocytosis nos (VeDDRA 163). See the species, breeds, and drugs most associated with it below.

7,187
reports citing this reaction
30.4%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
7,187
Total Reports
2,185
Deaths
30.4%
Death Rate

Species Most Affected

Dog 6,089
Cat 1,023
Horse 59
Human 5
Cattle 3
Other 2
Rabbit 2
Pig 1
Donkey 1
Fish 1

Breeds Most Affected

Retriever - Labrador 808
Domestic Shorthair 565
Crossbred Canine/dog 468
Retriever - Golden 281
Shepherd Dog - German 257
Chihuahua 256
Shih Tzu 195
Terrier - Yorkshire 162
Boxer (German Boxer) 150
Pug 128

Associated Drugs

Carprofen 1,056
Maropitant Citrate 777
Milbemycin Oxime + Spinosad 483
Moxidectin 427
Prednisone 388
Afoxolaner 381
Bedinvetmab 350
Oclacitinib Maleate 336
Cefovecin 310
Fluralaner Chew Tablets 297
Gabapentin 272
Meloxicam 247
Trilostane 243
Enrofloxacin 229
Spinosad 227
Famotidine 221
Ivermectin + Pyrantel As Pamoate Salt 217
Doxycycline 208
Deracoxib 206
Metronidazole 203

Leucocytosis NOS Reaction Insights

7,187 reports name Leucocytosis NOS; 2,185 recorded a death outcome (30.4% of reported events, not a population-level mortality rate). VeDDRA code: 163.

By species: Dog (6,089 reports), Cat (1,023 reports), Horse (59 reports). By breed: Retriever - Labrador (808), Domestic Shorthair (565), Crossbred Canine/dog (468).

Most co-reported drugs: Carprofen (1,056 reports), Maropitant Citrate (777 reports), Milbemycin Oxime + Spinosad (483 reports), Moxidectin (427 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.