Drug profile

The FDA adverse-event record for Rabies Vaccine, Killed Virus

455 FDA reports name Rabies Vaccine, Killed Virus, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#325 of 2,679
by report volume (all drugs)
455
adverse-event reports
10.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Rabies Vaccine, Killed Virus ranks #323 of 2679 by total reports (455) and #533 of 1130 by death-coded share (10.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#323
This drug, reports of 2679
#533
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Rabies Vaccine, Killed Virus has 455 reports now versus 455 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Rabies Vaccine, Killed Virus changes

Signature read: 455 reports place Rabies Vaccine, Killed Virus in the upper third of FDA AER volume (#325 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
455
Total Reports
47
Deaths Reported
10.3%
Death-coded share of reports

Active Ingredients

Rabies Vaccine, Killed Virus

Administration Routes

SubcutaneousParenteralUnknownIntramuscularOralTransdermalOther

Species Affected

Dog 357
Cat 97
Horse 1

Most Affected Breeds

Domestic Shorthair 66
Retriever - Labrador 34
Chihuahua 31
Shih Tzu 23
Retriever - Golden 21
Domestic Longhair 16
Dachshund (unspecified) 14
Pit Bull 13
Terrier - Yorkshire 13
Shepherd Dog - Australian 13

Most Reported Reactions

Vomiting 108
Lethargy (see also Central nervous system depression in 'Neurological') 59
Other abnormal test result NOS 49
Diarrhoea 44
Not eating 43
Facial swelling (see also 'Skin') 42
Anaphylaxis 36
Lethargy (see also Central nervous system depression in Neurological) 30
Pale mucous membrane 29
Death 27
Fever 25
Weight loss 25

Outcome Breakdown

Recovered/Normal
154 (33.8%)
Outcome Unknown
151 (33.2%)
Ongoing
98 (21.5%)
Died
34 (7.5%)
Euthanized
13 (2.9%)
Recovered with Sequela
5 (1.1%)

Rabies Vaccine, Killed Virus: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Rabies Vaccine, Killed Virus, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (455 here).

Similar death-coded share

Nearest other drugs by death-coded share (10.3% here), distinct from the volume row.

What to do with this drug

  • Compare Rabies Vaccine, Killed Virus's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Rabies Vaccine, Killed Virus (#325 of 2,679 by report volume); death-coded 10.3%. PlainBreed drug row · report volume stamp 455 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →