Drug profile

The FDA adverse-event record for Dapp

349 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Dapp. See the species affected, top reactions, and outcomes below.

349
adverse-event reports
10.0%
death-coded share
Dog
most-reported species
110
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
349
Total Reports
35
Deaths Reported
10.0%
Death Rate

Active Ingredients

Dapp

Administration Routes

UnknownSubcutaneousNasal

Species Affected

Dog 346
Cat 2
Other 1

Most Affected Breeds

Retriever - Labrador 34
Terrier - Bull - American Pit 30
Terrier - Yorkshire 22
Chihuahua 19
Crossbred Canine/dog 16
Boxer (German Boxer) 14
Shih Tzu 13
Shepherd Dog - German 10
Retriever - Golden 10
Schnauzer - Miniature 10

Most Reported Reactions

Vomiting 110
Lethargy (see also Central nervous system depression in 'Neurological') 63
Facial swelling (see also 'Skin') 52
Diarrhoea 49
Anaphylaxis 44
Hives (see also 'Skin') 43
Seizure NOS 31
Fever 29
Anorexia 26
Emesis 23
Death 22
Pale mucous membrane 22

Outcome Breakdown

Ongoing
176 (50.3%)
Recovered/Normal
116 (33.1%)
Died
23 (6.6%)
Outcome Unknown
23 (6.6%)
Euthanized
12 (3.4%)

Dapp Adverse Event Insights

349 reports name Dapp; 35 recorded a death outcome (10.0% of reported events, not a population-level mortality rate). Active ingredient: Dapp. Administration routes: Unknown, Subcutaneous, Nasal.

By species: Dog (346 reports), Cat (2 reports), Other (1 reports). By breed: Retriever - Labrador (34), Terrier - Bull - American Pit (30), Terrier - Yorkshire (22).

Leading clinical signs: Vomiting (110), Lethargy (see also Central nervous system depression in 'Neurological') (63), Facial swelling (see also 'Skin') (52), Diarrhoea (49). Outcome, 350 coded reports: Ongoing leads at 50.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.