Drug profile

The FDA adverse-event record for Sometribove

556 FDA reports name Sometribove, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#280 of 2,679
by report volume (all drugs)
556
adverse-event reports
4.7%
death-coded share
Cattle
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Sometribove ranks #279 of 2679 by total reports (556) and #804 of 1130 by death-coded share (4.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#279
This drug, reports of 2679
#804
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Sometribove has 556 reports now versus 556 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Sometribove changes

Signature read: 556 reports place Sometribove in the upper third of FDA AER volume (#280 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
556
Total Reports
26
Deaths Reported
4.7%
Death-coded share of reports

Active Ingredients

Sometribove

Administration Routes

UnknownParenteralSubcutaneousOralCutaneous

Species Affected

Cattle 422
Unknown 118
Human 16

Most Affected Breeds

Holstein-Friesian also known as Holstein 257
Unknown 134
Cattle (unknown) 68
Jersey 30
Crossbred Bovine/Cattle 27
Mixed (Cattle) 26
Cattle (other) 3
Guernsey 2
Holstein-Friesian - French Black Pied 2
Shorthorn - Milking 2

Most Reported Reactions

INEFFECTIVE, PRODUCTION (MILK) 168
Milk production decrease 76
Product syringe issue 71
Mastitis NOS 59
Product problem 57
Alteration of milk quality 46
Lack of efficacy - NOS 38
Syringe, Abnormal 24
Death 23
Mammary gland disorder NOS 20
Abnormal number of offspring 18
Reduced conception rate 17

Outcome Breakdown

Outcome Unknown
288 (68.9%)
Recovered/Normal
76 (18.2%)
Died
24 (5.7%)
Ongoing
16 (3.8%)
Recovered with Sequela
12 (2.9%)
Euthanized
2 (0.5%)

Sometribove: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Sometribove, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (4.7% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Sometribove (#280 of 2,679 by report volume); death-coded 4.7%. PlainBreed drug row · report volume stamp 556 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →