Drug profile

The FDA adverse-event record for Minocycline

63 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Minocycline. See the species affected, top reactions, and outcomes below.

63
adverse-event reports
7.9%
death-coded share
Dog
most-reported species
12
Emesis - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
63
Total Reports
5
Deaths Reported
7.9%
Death Rate

Active Ingredients

Minocycline

Administration Routes

OralUnknown

Species Affected

Dog 60
Horse 2
Cat 1

Most Affected Breeds

Retriever - Labrador 11
Shepherd Dog - German 5
Chihuahua 4
Crossbred Canine/dog 4
Shepherd Dog - Australian 3
Sheepdog - Shetland 3
Bichon Frise 2
Terrier - Jack Russell 2
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2
Dachshund (unspecified) 2

Most Reported Reactions

Emesis 12
Other abnormal test result NOS 11
Lack of efficacy - NOS 10
INEFFECTIVE, HEARTWORM LARVAE 10
Lethargy (see also Central nervous system depression in 'Neurological') 9
Vomiting 9
Anorexia 8
Behavioural disorder NOS 7
Weight loss 5
Weight gain 5
Lack of efficacy (endoparasite) - heartworm 5
Abnormal radiograph finding 4

Outcome Breakdown

Recovered/Normal
26 (41.3%)
Outcome Unknown
22 (34.9%)
Ongoing
8 (12.7%)
Euthanized
3 (4.8%)
Recovered with Sequela
2 (3.2%)
Died
2 (3.2%)

Minocycline Adverse Event Insights

63 reports name Minocycline; 5 recorded a death outcome (7.9% of reported events, not a population-level mortality rate). Active ingredient: Minocycline. Administration routes: Oral, Unknown.

By species: Dog (60 reports), Horse (2 reports), Cat (1 reports). By breed: Retriever - Labrador (11), Shepherd Dog - German (5), Chihuahua (4).

Leading clinical signs: Emesis (12), Other abnormal test result NOS (11), Lack of efficacy - NOS (10), INEFFECTIVE, HEARTWORM LARVAE (10). Outcome, 63 coded reports: Recovered/Normal leads at 41.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.