Fipronil + (S)-Methoprene
367 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
367
Total Reports
6
Deaths Reported
160.0%
Death Rate
Active Ingredients
Fipronil + (S)-Methoprene
Administration Routes
TopicalUnknownOralCutaneousIntraocular
Species Affected
Dog 305
Cat 62
Most Affected Breeds
Retriever - Labrador 41
Domestic Shorthair 24
Dog (unknown) 17
Crossbred Canine/dog 15
Cat (unknown) 15
Shepherd Dog - German 13
Domestic Longhair 11
Shih Tzu 9
Shepherd Dog - Australian 9
Dachshund (unspecified) 8
Most Reported Reactions
Emesis 94
Lack of efficacy (ectoparasite) - flea 67
Vomiting 46
Lethargy (see also Central nervous system depression in 'Neurological') 42
Lack of efficacy - NOS 40
Diarrhoea 18
Behavioural disorder NOS 16
Other abnormal test result NOS 16
Lack of efficacy (flea) 14
Lack of efficacy (endoparasite) - heartworm 14
Panting 12
Seizure NOS 11
Outcome Breakdown
Outcome Unknown
158 (43.1%)
Recovered/Normal
147 (40.1%)
Ongoing
40 (10.9%)
Recovered with Sequela
16 (4.4%)
Died
5 (1.4%)
Euthanized
1 (0.3%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.