Fipronil 10%/S Methoprene 9% Spot On
1,422 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,422
Total Reports
23
Deaths Reported
160.0%
Death Rate
Active Ingredients
Fipronil 10%/S Methoprene 9% Spot On
Administration Routes
UnknownOtherTopicalOralSubcutaneousSublingualTransdermal
Species Affected
Dog 1,420
Human 1
Cat 1
Most Affected Breeds
Retriever - Labrador 151
Crossbred Canine/dog 89
Dog (unknown) 85
Retriever - Golden 73
Shih Tzu 68
Terrier - Yorkshire 55
Dog (other) 53
Chihuahua 47
Shepherd Dog - German 40
Maltese 29
Most Reported Reactions
Vomiting 326
Lethargy (see also Central nervous system depression in 'Neurological') 254
Lack of efficacy (ectoparasite) - flea 115
Behavioural disorder NOS 113
Diarrhoea 111
Seizure NOS 110
Skin disorders NOS 107
Lack of efficacy - NOS 61
Anorexia 50
Application site irritation 49
Pruritus 48
Scratching 46
Outcome Breakdown
Outcome Unknown
784 (55.1%)
Recovered/Normal
554 (38.9%)
Ongoing
60 (4.2%)
Euthanized
12 (0.8%)
Died
11 (0.8%)
Recovered with Sequela
3 (0.2%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.