Drug profile

The FDA adverse-event record for Fipronil 10%/S Methoprene 9% Spot On

1,422 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Fipronil 10%/S Methoprene 9% Spot On. See the species affected, top reactions, and outcomes below.

1,422
adverse-event reports
1.6%
death-coded share
Dog
most-reported species
326
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,422
Total Reports
23
Deaths Reported
1.6%
Death Rate

Active Ingredients

Fipronil 10%/S Methoprene 9% Spot On

Administration Routes

UnknownOtherTopicalOralSubcutaneousSublingualTransdermal

Species Affected

Dog 1,420
Human 1
Cat 1

Most Affected Breeds

Retriever - Labrador 151
Crossbred Canine/dog 89
Dog (unknown) 85
Retriever - Golden 73
Shih Tzu 68
Terrier - Yorkshire 55
Dog (other) 53
Chihuahua 47
Shepherd Dog - German 40
Maltese 29

Most Reported Reactions

Vomiting 326
Lethargy (see also Central nervous system depression in 'Neurological') 254
Lack of efficacy (ectoparasite) - flea 115
Behavioural disorder NOS 113
Diarrhoea 111
Seizure NOS 110
Skin disorders NOS 107
Lack of efficacy - NOS 61
Anorexia 50
Application site irritation 49
Pruritus 48
Scratching 46

Outcome Breakdown

Outcome Unknown
784 (55.1%)
Recovered/Normal
554 (38.9%)
Ongoing
60 (4.2%)
Euthanized
12 (0.8%)
Died
11 (0.8%)
Recovered with Sequela
3 (0.2%)

Fipronil 10%/S Methoprene 9% Spot On Adverse Event Insights

1,422 reports name Fipronil 10%/S Methoprene 9% Spot On; 23 recorded a death outcome (1.6% of reported events, not a population-level mortality rate). Active ingredient: Fipronil 10%/S Methoprene 9% Spot On. Administration routes: Unknown, Other, Topical, Oral.

By species: Dog (1,420 reports), Human (1 reports), Cat (1 reports). By breed: Retriever - Labrador (151), Crossbred Canine/dog (89), Dog (unknown) (85).

Leading clinical signs: Vomiting (326), Lethargy (see also Central nervous system depression in 'Neurological') (254), Lack of efficacy (ectoparasite) - flea (115), Behavioural disorder NOS (113). Outcome, 1,424 coded reports: Outcome Unknown leads at 55.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.