Drug profile

The FDA adverse-event record for Molidustat

386 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Molidustat. See the species affected, top reactions, and outcomes below.

386
adverse-event reports
12.2%
death-coded share
Cat
most-reported species
105
Lack of efficacy - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
386
Total Reports
47
Deaths Reported
12.2%
Death Rate

Active Ingredients

Molidustat

Administration Routes

OralUnknownTopicalOphthalmicIntraocularIntravenous

Species Affected

Cat 342
Unknown 43
Dog 1

Most Affected Breeds

Domestic Shorthair 185
Cat (unknown) 70
Unknown 43
Domestic Longhair 34
Domestic Mediumhair 15
Siamese 7
Persian 7
Maine Coon 6
Russian 3
Ragdoll 3

Most Reported Reactions

Lack of efficacy - NOS 105
Vomiting 49
Decreased haematocrit 38
Weight loss 37
Elevated creatinine 34
Death by euthanasia 33
Lethargy (see also Central nervous system depression in Neurological) 31
Pica NOS 30
Elevated blood urea nitrogen (BUN) 29
Decreased appetite 28
Not eating 28
Other abnormal test result NOS 26

Outcome Breakdown

Outcome Unknown
169 (49.0%)
Ongoing
98 (28.4%)
Euthanized
31 (9.0%)
Recovered/Normal
31 (9.0%)
Died
16 (4.6%)

Molidustat Adverse Event Insights

386 reports name Molidustat; 47 recorded a death outcome (12.2% of reported events, not a population-level mortality rate). Active ingredient: Molidustat. Administration routes: Oral, Unknown, Topical, Ophthalmic.

By species: Cat (342 reports), Unknown (43 reports), Dog (1 reports). By breed: Domestic Shorthair (185), Cat (unknown) (70), Unknown (43).

Leading clinical signs: Lack of efficacy - NOS (105), Vomiting (49), Decreased haematocrit (38), Weight loss (37). Outcome, 345 coded reports: Outcome Unknown leads at 49.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.