Fipronil + S-Methoprene
812 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
812
Total Reports
49
Deaths Reported
600.0%
Death Rate
Active Ingredients
FipronilFipronil + S-MethopreneS-Methoprene
Administration Routes
TopicalOtherUnknownOralSubconjunctival
Species Affected
Dog 762
Cat 49
Goat 1
Most Affected Breeds
Dog (unknown) 54
Retriever - Labrador 51
Retriever - Golden 47
Crossbred Canine/dog 39
Chihuahua 38
Spaniel - King Charles Cavalier 32
Terrier - Yorkshire 30
Shepherd Dog - German 27
Shih Tzu 23
Domestic Shorthair 22
Most Reported Reactions
Lack of efficacy (ectoparasite) - flea 255
Vomiting 86
Seizure NOS 58
Lack of efficacy (ectoparasite) - tick NOS 52
Lethargy (see also Central nervous system depression in 'Neurological') 49
Diarrhoea 45
Death 28
Shaking 27
Behavioural disorder NOS 25
Lack of efficacy (bacteria) - NOS 25
Lack of efficacy (bacteria) - Borrelia 25
Lack of efficacy (tick) 23
Outcome Breakdown
Outcome Unknown
505 (62.0%)
Recovered/Normal
195 (23.9%)
Ongoing
64 (7.9%)
Died
29 (3.6%)
Euthanized
20 (2.5%)
Recovered with Sequela
2 (0.2%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.