Drug profile

The FDA adverse-event record for Ivermectin 34Mcg, Pyrantel Pamoate 28.5Mg, Praziquantel 28.5Mg

844 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ivermectin 34Mcg, Pyrantel Pamoate 28.5Mg, Praziquantel 28.5Mg. See the species affected, top reactions, and outcomes below.

844
adverse-event reports
0.8%
death-coded share
Dog
most-reported species
568
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
844
Total Reports
7
Deaths Reported
0.8%
Death Rate

Active Ingredients

Ivermectin 34Mcg, Pyrantel Pamoate 28.5Mg, Praziquantel 28.5Mg

Administration Routes

OralUnknown

Species Affected

Dog 789
Unknown 48
Human 5
Cat 2

Most Affected Breeds

Chihuahua 160
Terrier - Yorkshire 139
Maltese 91
Unknown 53
Shih Tzu 48
Spitz - German Pomeranian 38
Poodle - Standard 30
Crossbred Canine/dog 29
Dachshund (unspecified) 29
Poodle - Toy 27

Most Reported Reactions

Vomiting 568
Lethargy (see also Central nervous system depression in 'Neurological') 135
Diarrhoea 99
INEFFECTIVE, HEARTWORM LARVAE 58
Lack of efficacy - NOS 35
Underfilling, Package 32
Lack of efficacy (endoparasite) - hookworm 26
Uncoded sign 26
Overdose 26
Shaking 22
Behavioural disorder NOS 22
INEFFECTIVE, ASCARIDS NOS 18

Outcome Breakdown

Recovered/Normal
578 (72.6%)
Outcome Unknown
204 (25.6%)
Recovered with Sequela
4 (0.5%)
Died
4 (0.5%)
Ongoing
3 (0.4%)
Euthanized
3 (0.4%)

Ivermectin 34Mcg, Pyrantel Pamoate 28.5Mg, Praziquantel 28.5Mg Adverse Event Insights

844 reports name Ivermectin 34Mcg, Pyrantel Pamoate 28.5Mg, Praziquantel 28.5Mg; 7 recorded a death outcome (0.8% of reported events, not a population-level mortality rate). Active ingredient: Ivermectin 34Mcg, Pyrantel Pamoate 28.5Mg, Praziquantel 28.5Mg. Administration routes: Oral, Unknown.

By species: Dog (789 reports), Unknown (48 reports), Human (5 reports). By breed: Chihuahua (160), Terrier - Yorkshire (139), Maltese (91).

Leading clinical signs: Vomiting (568), Lethargy (see also Central nervous system depression in 'Neurological') (135), Diarrhoea (99), INEFFECTIVE, HEARTWORM LARVAE (58). Outcome, 796 coded reports: Recovered/Normal leads at 72.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.