Fipronil, Cyphenothrin, (S)-Methoprene

51 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

200.0%

Death Rate

Active Ingredients

Fipronil, Cyphenothrin, (S)-Methoprene

Administration Routes

TopicalOralUnknown

Species Affected

Dog 51

Most Affected Breeds

Dog (unknown) 8

Shepherd Dog - Australian 4

Terrier - Yorkshire 4

Pit Bull 4

Shepherd Dog - German 3

Retriever - Labrador 2

Spaniel - King Charles Cavalier 2

Newfoundland 2

Beagle 2

Spitz - German Pomeranian 2

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 40

Scratching 6

Rash 3

Lack of efficacy - NOS 3

General hair loss 2

Tremor 2

Itching 2

Reddening of the skin 2

Skin irritation 2

Hives (see also Skin) 2

Cough 1

Lethargy (see also Central nervous system depression in 'Neurological') 1

Outcome Breakdown

Outcome Unknown

48 (94.1%)

Ongoing

1 (2.0%)

Recovered/Normal

1 (2.0%)

Died

1 (2.0%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.