Drug profile

The FDA adverse-event record for Crystalloid Fluids

66 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Crystalloid Fluids. Species, reactions, and outcomes follow.

#962 of 2,679
by report volume (all drugs)
66
adverse-event reports
33.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Crystalloid Fluids ranks #959 of 2679 by total reports (66) and #107 of 1130 by death-coded share (33.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#959
This drug, reports of 2679
#107
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Crystalloid Fluids has 66 reports now versus 63 in that prior snapshot: 3 more (4.8%).

Report change
+3
Death-coded reports
+0
Death-coded share
−1.6 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Crystalloid Fluids changes

Signature read: Crystalloid Fluids's 33.3% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
66
Total Reports
22
Deaths Reported
33.3%
Death-coded share of reports

Active Ingredients

Crystalloid Fluids

Administration Routes

UnknownIntravenousSubcutaneousIntrauterine

Species Affected

Dog 35
Cat 30
Cattle 1

Most Affected Breeds

Domestic Shorthair 16
Retriever - Labrador 5
Retriever - Golden 4
Crossbred Canine/dog 3
Domestic Longhair 3
Domestic Mediumhair 3
Beagle 2
Dog (unknown) 2
Spaniel - Springer English 2
Doberman Pinscher 2

Most Reported Reactions

Vomiting 15
Other abnormal test result NOS 13
Not eating 13
Weight loss 12
Anorexia 10
Death 10
Lethargy (see also Central nervous system depression in Neurological) 10
Dehydration 9
Abnormal ultrasound finding 9
Death by euthanasia 9
Behavioural disorder NOS 9
Hyperglycaemia 9

Outcome Breakdown

Ongoing
18 (26.9%)
Outcome Unknown
16 (23.9%)
Died
13 (19.4%)
Recovered/Normal
11 (16.4%)
Euthanized
9 (13.4%)

Crystalloid Fluids: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Crystalloid Fluids, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Crystalloid Fluids (#962 of 2,679 by report volume); death-coded 33.3%. PlainBreed drug row · death-coded share stamp 33.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →