Drug profile

The FDA adverse-event record for Compounded Trilostane

65 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Compounded Trilostane. See the species affected, top reactions, and outcomes below.

65
adverse-event reports
7.7%
death-coded share
Dog
most-reported species
14
Underdose - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
65
Total Reports
5
Deaths Reported
7.7%
Death Rate

Active Ingredients

Compounded Trilostane

Administration Routes

OralUnknown

Species Affected

Dog 65

Most Affected Breeds

Chihuahua 8
Terrier - Boston 4
Dog (unknown) 4
Maltese 4
Terrier - Yorkshire 4
Spaniel (unspecified) 3
Dachshund - Miniature 3
Beagle 3
Retriever - Labrador 3
Dachshund - Standard Long-haired 3

Most Reported Reactions

Underdose 14
INEFFECTIVE, CUSHINGS 9
Lethargy (see also Central nervous system depression in 'Neurological') 9
Elevated serum alkaline phosphatase (SAP) 9
Anorexia 8
Lack of efficacy - NOS 7
Hypoadrenocorticism 7
Diarrhoea 7
Elevated alanine aminotransferase (ALT) 7
Proteinuria 7
Polyuria 6
Abnormal adrenocorticotropic hormone (ACTH) stimulation test 6

Outcome Breakdown

Outcome Unknown
48 (73.8%)
Recovered/Normal
7 (10.8%)
Euthanized
4 (6.2%)
Ongoing
4 (6.2%)
Died
1 (1.5%)
Recovered with Sequela
1 (1.5%)

Compounded Trilostane Adverse Event Insights

65 reports name Compounded Trilostane; 5 recorded a death outcome (7.7% of reported events, not a population-level mortality rate). Active ingredient: Compounded Trilostane. Administration routes: Oral, Unknown.

By species: Dog (65 reports). By breed: Chihuahua (8), Terrier - Boston (4), Dog (unknown) (4).

Leading clinical signs: Underdose (14), INEFFECTIVE, CUSHINGS (9), Lethargy (see also Central nervous system depression in 'Neurological') (9), Elevated serum alkaline phosphatase (SAP) (9). Outcome, 65 coded reports: Outcome Unknown leads at 73.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.