Milbemycin/Lufenuron/Pzq Chew
4,022 adverse event reports submitted to the FDA
Active Ingredients
Administration Routes
Species Affected
Most Affected Breeds
Most Reported Reactions
Outcome Breakdown
Data Summary
| Metric | Value |
|---|---|
| Total adverse event reports | 4,022 |
| Reports involving death | 64 |
| Case-fatality rate (reported events) | 160.0% |
| Distinct species in reports | 2 |
| Distinct breeds in reports | 20 |
| Distinct reactions reported | 20 |
| Active ingredients on file | 1 |
Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.
Milbemycin/Lufenuron/Pzq Chew Adverse Event Insights
The FDA Center for Veterinary Medicine database currently holds 4,022 adverse event reports referencing Milbemycin/Lufenuron/Pzq Chew, including 64 reports in which the animal died — a 160.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Milbemycin/Lufenuron/Pzq Chew. Reported administration routes include Oral, Unknown, Dental, Oculonasal. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.
The species most frequently named in Milbemycin/Lufenuron/Pzq Chew reports are Dog (3,934 reports), Unknown (88 reports), with Dog accounting for the largest share. Within those species, Crossbred Canine/dog (1,084), Retriever - Labrador (430), Shepherd Dog - German (191) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.
The most commonly reported clinical signs associated with Milbemycin/Lufenuron/Pzq Chew are Lack of efficacy (endoparasite) - heartworm (1,316), Lack of efficacy (endoparasite) - hookworm (630), Vomiting (448), Lack of efficacy (endoparasite) - roundworm NOS (340). Of the 3,935 reports with a coded outcome, Ongoing is the leading category at 72.5%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Milbemycin/Lufenuron/Pzq Chew.
Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates
Read our methodology — how this data is sourced, computed, and verified.