Milbemycin Oxime + Spinosad

149,298 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

149,298

Total Reports

3,462

Deaths Reported

230.0%

Death Rate

Active Ingredients

Milbemycin OximeMilbemycin Oxime + SpinosadSpinosad

Administration Routes

OralUnknownCutaneousOtherTopicalRespiratory (Inhalation)IntraocularIntramammarySubcutaneousTransdermal

Species Affected

Dog 138,407

Unknown 10,344

Cat 297

Human 237

Other Canids 7

Other 3

Wolf 2

Fish 1

Most Affected Breeds

Retriever - Labrador 16,498

Unknown 10,636

Crossbred Canine/dog 6,856

Chihuahua 6,085

Retriever - Golden 5,536

Shepherd Dog - German 5,496

Terrier - Yorkshire 5,198

Dog (unknown) 5,114

Boxer (German Boxer) 4,949

Shih Tzu 4,835

Most Reported Reactions

Emesis 43,142

Vomiting 33,623

Lethargy (see also Central nervous system depression in 'Neurological') 20,659

Lack of efficacy - NOS 13,054

UNPALATABLE 12,118

INEFFECTIVE, HEARTWORM LARVAE 7,899

Lack of efficacy (endoparasite) - heartworm 7,382

Lack of efficacy (ectoparasite) - flea 7,020

Diarrhoea 6,950

Seizure NOS 4,381

Weight gain 4,225

Behavioural disorder NOS 4,102

Outcome Breakdown

Recovered/Normal

80,586 (58.0%)

Outcome Unknown

39,980 (28.8%)

Ongoing

7,947 (5.7%)

Recovered with Sequela

7,021 (5.1%)

Died

2,221 (1.6%)

Euthanized

1,244 (0.9%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.